Evidence map›Paper›PMID 26423072›Full record

ArticleInternal and emergency medicine2016

Prognostic implications of heart failure with preserved ejection fraction in patients with an exacerbation of chronic obstructive pulmonary disease.

Robert Marcun, Ivan Stankovic, Radosav Vidakovic, Jerneja Farkas, Sasa Kadivec, Biljana Putnikovic, Ivan Ilic, Aleksandar N Neskovic, Mitja Lainscak

Abstract read
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In one paragraph

Article in Internal and emergency medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. NT-proBNP in Different Patient Groups of COPD: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2023
    Pooled it
  4. Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.American journal of respiratory and critical care medicine · 2017
    Trial
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Robert MarcunUniversity Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia.
Ivan StankovicDepartment of Cardiology, Faculty of Medicine, Clinical Hospital Center Zemun, University of Belgrade, Belgrade, Serbia. future.ivan@gmail.com.
Radosav VidakovicDepartment of Cardiology, Faculty of Medicine, Clinical Hospital Center Zemun, University of Belgrade, Belgrade, Serbia.
Jerneja FarkasChair of Public Health, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Sasa KadivecUniversity Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia.
Biljana PutnikovicDepartment of Cardiology, Faculty of Medicine, Clinical Hospital Center Zemun, University of Belgrade, Belgrade, Serbia.
Ivan IlicDepartment of Cardiology, Faculty of Medicine, Clinical Hospital Center Zemun, University of Belgrade, Belgrade, Serbia.
Aleksandar N NeskovicDepartment of Cardiology, Faculty of Medicine, Clinical Hospital Center Zemun, University of Belgrade, Belgrade, Serbia.
Mitja LainscakDepartment of Cardiology, General Hospital Celje, Oblakova cesta 5, 3000, Celje, Slovenia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diagnosing heart failure with preserved ejection fraction (HFpEF) in patients with chronic obstructive pulmonary disease (COPD) is difficult due to overlapping pathophysiological pathways, risk factors and clinical presentations. We investigated the prevalence and prognostic implications of coexisting HFpEF in patients hospitalized for acute exacerbation of COPD. A total of 116 consecutive patients with an acute exacerbation of COPD were evaluated for HFpEF and followed for an average period of 22 ± 9 months for the occurrence of death from any cause. HFpEF was diagnosed in 22 (19 %) patients with COPD, who were older, and also had higher LV mass, left atrial size, and mitral E/Ea ratio than those without HFpEF (p < 0.05 for all comparisons). HFpEF was not independently associated with all-cause mortality [hazard ratio (HR) 1.07, 95 % confidence interval (CI) 0.44-2.62]. Global initiative for chronic Obstructive Lung Disease (GOLD) stage (IV vs. I-III, HR 2.37, CI 1.23-4.59) and N-terminal pro B-type natriuretic peptide (NT-proBNP) levels (HR 2.79, CI 1.12-6.98) were independent predictors of long-term survival. HFpEF is present in one-fifth of patients with exacerbated COPD. Non-invasively diagnosed HFpEF may not be an independent predictor of all-cause mortality. Elevated NT-proBNP levels and very severe COPD were independently associated with unfavorable overall survival.

Indexed as

AgedBiomarkersEchocardiographyFemaleHeart FailureHospitalizationHumansMaleNatriuretic Peptide, BrainPeptide FragmentsPrognosisProspective StudiesPulmonary Disease, Chronic ObstructiveRespiratory Function TestsRisk FactorsStroke VolumeBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Chronic obstructive pulmonary diseaseHeart failure with preserved ejection fractionOutcomePrevalence

Identifiers

PMID26423072

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.