ArticleMolecular genetics and genomics : MGG2016
Structural features of conopeptide genes inferred from partial sequences of the Conus tribblei genome.
Article in Molecular genetics and genomics : MGG, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 41 citations in OpenAlex.
- The high-quality genome of Bellamya aeruginosa reveals the molecular mechanisms underlying its remarkable stress resistance.BMC biology · 2025Article
- Systematic dissection of genomic features determining the vast diversity of conotoxins.BMC genomics · 2023Article
- Whole Genome Duplication and Gene Evolution in the Hyperdiverse Venomous Gastropods.Molecular biology and evolution · 2023Article
- Chromosome-level genome of the venomous snail Kalloconus canariensis: a valuable model for venomics and comparative genomics.GigaScience · 2022Article
- Biomedical Potential of the Neglected Molluscivorous and VermivorousMarine drugs · 2022Review
- High-Throughput Prediction and Design of Novel Conopeptides for Biomedical Research and Development.Biodesign research · 2022Article
- How many single-copy orthologous genes from whole genomes reveal deep gastropod relationships?PeerJ · 2022Article
- Draft genome of Semisulcospira libertina, a species of freshwater snail.Genomics & informatics · 2021Article
- The genome of the venomous snail Lautoconus ventricosus sheds light on the origin of conotoxin diversity.GigaScience · 2021Article
- Mobilizing molluscan models and genomes in biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone SnailMarine drugs · 2021Article
- The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus.Cell discovery · 2021Article
- The Iron-Responsive Genome of the Chiton Acanthopleura granulata.Genome biology and evolution · 2021Article
- Sequencing of Transcriptome and Small RNA Revealed the Xenobiotic Metabolism-Related Genes and Potential Regulatory miRNA in Asian Tramp Snail.Frontiers in genetics · 2020Article
- Article
- The survey and reference assisted assembly of the Octopus vulgaris genome.Scientific data · 2019Article
- Article
- Targeted Sequencing of Venom Genes from Cone Snail Genomes Improves Understanding of Conotoxin Molecular Evolution.Molecular biology and evolution · 2018Article
- Brute-Force Approach for Mass Spectrometry-Based Variant Peptide Identification in Proteogenomics without Personalized Genomic Data.Journal of the American Society for Mass Spectrometry · 2018Article
- Transcriptome sequencing and differential gene expression analysis of the schistosome-transmitting snail Oncomelania hupensis inhabiting hilly and marshland regions.Scientific reports · 2017Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolvability of venom components (in particular, the gene-encoded peptide toxins) in venomous species serves as an adaptive strategy allowing them to target new prey types or respond to changes in the prey field. The structure, organization, and expression of the venom peptide genes may provide insights into the molecular mechanisms that drive the evolution of such genes. Conus is a particularly interesting group given the high chemical diversity of their venom peptides, and the rapid evolution of the conopeptide-encoding genes. Conus genomes, however, are large and characterized by a high proportion of repetitive sequences. As a result, the structure and organization of conopeptide genes have remained poorly known. In this study, a survey of the genome of Conus tribblei was undertaken to address this gap. A partial assembly of C. tribblei genome was generated; the assembly, though consisting of a large number of fragments, accounted for 2160.5 Mb of sequence. A large number of repetitive genomic elements consisting of 642.6 Mb of retrotransposable elements, simple repeats, and novel interspersed repeats were observed. We characterized the structural organization and distribution of conotoxin genes in the genome. A significant number of conopeptide genes (estimated to be between 148 and 193) belonging to different superfamilies with complete or nearly complete exon regions were observed, ~60 % of which were expressed. The unexpressed conopeptide genes represent hidden but significant conotoxin diversity. The conotoxin genes also differed in the frequency and length of the introns. The interruption of exons by long introns in the conopeptide genes and the presence of repeats in the introns may indicate the importance of introns in facilitating recombination, evolution and diversification of conotoxins. These findings advance our understanding of the structural framework that promotes the gene-level molecular evolution of venom peptides.
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