Evidence map›Paper›PMID 26423007›Full record

ReviewDental materials : official publication of the Academy of Dental Materials2016

Design and characterization of calcium phosphate ceramic scaffolds for bone tissue engineering.

Isabelle Denry, Liisa T Kuhn

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dental materials : official publication of the Academy of Dental Materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Isabelle DenryDepartment of Prosthodontics, University of Iowa College of Dentistry, 801 Newton Road, Iowa City, IA 52242-1010, USA. Electronic address: Isabelle-Denry@uiowa.edu.
Liisa T KuhnDepartment of Reconstructive Sciences, UConn Health, 263 Farmington Avenue, MC 1615, Farmington, CT 06030-1615, USA.

Funding

Modulated release of growth factors for stimulating progenitors in aging boneR01DE021103 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUHN, LIISA TIINA · 2012 to 2025
$4.4M
Ceramic scaffolds with engineered topography and chemistryR01DE019972 · NIDCR · UNIVERSITY OF IOWA · PI DENRY, ISABELLE L · 2010 to 2014
$1.8M
NIDCR NIH HHS R01 DE019972NIDCR NIH HHS R01DE019972NIDCR NIH HHS R01 DE021103NIDCR NIH HHS R01DE021103
6 · The paper itself

Abstract

objectivesOur goal is to review design strategies for the fabrication of calcium phosphate ceramic scaffolds (CPS), in light of their transient role in bone tissue engineering and associated requirements for effective bone regeneration.

methodsWe examine the various design options available to meet mechanical and biological requirements of CPS and later focus on the importance of proper characterization of CPS in terms of architecture, mechanical properties and time-sensitive properties such as biodegradability. Finally, relationships between in vitro versus in vivo testing are addressed, with an attempt to highlight reliable performance predictors.

resultsA combinatory design strategy should be used with CPS, taking into consideration 3D architecture, adequate surface chemistry and topography, all of which are needed to promote bone formation. CPS represent the media of choice for delivery of osteogenic factors and anti-infectives. Non-osteoblast mediated mineral deposition can confound in vitro osteogenesis testing of CPS and therefore the expression of a variety of proteins or genes including collagen type I, bone sialoprotein and osteocalcin should be confirmed in addition to increased mineral content.

conclusionsCPS are a superior scaffold material for bone regeneration because they actively promote osteogenesis. Biodegradability of CPS via calcium and phosphate release represents a unique asset. Structural control of CPS at the macro, micro and nanoscale and their combination with cells and polymeric materials is likely to lead to significant developments in bone tissue engineering.

Indexed as

Bone RegenerationBone SubstitutesCalcium PhosphatesCeramicsMaterials TestingMicroscopy, Electron, ScanningOsseointegrationOsteogenesisSurface PropertiesTissue EngineeringTissue ScaffoldsBioglassBone SubstitutesCalcium PhosphatesBioactive glassBone tissue engineeringCalcium phosphate ceramicHydroxyapatiteScaffold

Identifiers

PMID26423007
PMCPMC4696887

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.