Evidence map›Paper›PMID 26422622›Full record

ArticleKidney international2015

Epigenetic regulation in acute kidney injury: new light in a dark area.

Chengyuan Tang, Zheng Dong

Erratum issuedOpen access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. A cross talk between HIF and NF-κB in AKI.American journal of physiology. Renal physiology · 2021
    Article
  4. Article
  5. Review
  6. Article
  7. Renoprotective approaches and strategies in acute kidney injury.Pharmacology & therapeutics · 2016 · on this map
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Chengyuan TangDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zheng DongDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Augusta University · USCentral South University · CN

Funding

DNA methylation in kidney repair after ischemic AKIR01DK058831 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI DONG, ZHENG · 2001 to 2025
$7.5M
Kidney Injury by Cisplatin and Renoprotective Strategies.R01DK087843 · NIDDK · AUGUSTA UNIVERSITY · PI DONG, ZHENG · 2010 to 2025
$5.8M
Molecular Regulation of Ischemic Renal FailureI01BX000319 · VA · CHARLIE NORWOOD VA MEDICAL CENTER · PI Zheng Dong · 2009 to 2026
–
BLRD VA I01 BX000319NIDDK NIH HHS R01 DK058831NIDDK NIH HHS R01 DK087843
6 · The paper itself

Abstract

Epigenetic mechanisms have been implicated in the pathogenesis of renal diseases, including acute kidney injury (AKI). Mar et al. now unravel the acetylation and methylation at histones that are associated with the transcription of key genes in AKI. Notably, histone modifications display a remarkable heterogeneity in ischemic and endotoxic AKI. Targeting epigenetic programs may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery.

Indexed as

Epigenesis, GeneticKidneyLipopolysaccharidesAcute Kidney InjuryAnimalsMaleReperfusion InjuryLipopolysaccharides

Identifiers

PMID26422622
PMCPMC4734625
OpenAlexW2223615723

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.