Evidence map›Paper›PMID 26422605›Full record

Trial reportJournal of anxiety disorders2015

Defining treatment response in trichotillomania: a signal detection analysis.

David C Houghton, Matthew R Capriotti, Alessandro S De Nadai, Scott N Compton, Michael P Twohig, Angela M Neal-Barnett, Stephen M Saunders, Martin E Franklin, Douglas W Woods

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of anxiety disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02747771 (The Norwegian Trichotillomania Project), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02747771 recruitingnot on this map

The Norwegian Trichotillomania Project

TypeobservationalSponsorOslo University HospitalRan2013 to 2026Enrolled150ConditionsTrichotillomaniaArmsCognitive behavioral therapy
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Placebo response in trichotillomania.International clinical psychopharmacology · 2017
    Trial
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David C HoughtonTexas A&M University, Department of Psychology, 4235 TAMU, College Station, TX 77843, USA. Electronic address: davidhoughton@tamu.edu.
Matthew R CapriottiUniversity of California San Francisco, Department of Psychiatry, 401 Parnassus Ave., Box 0984, San Francisco, CA 94143, USA. Electronic address: matthew.capriotti@ucsf.edu.
Alessandro S De NadaiUniversity of South Florida, Department of Psychology, 4202 East Fowler Ave., PCD 4118G, Tampa, FL 33620, USA. Electronic address: denadai@mail.usf.edu.
Scott N ComptonDuke University School of Medicine, Department of Psychiatry and Behavioral Sciences, 2213 Elba St., Durham, NC 27705, USA. Electronic address: scompton@duke.edu.
Michael P TwohigUtah State University, Department of Psychology, 2810 Old Main Hill, Logan, UT 84322, USA. Electronic address: michael.twohig@usu.edu.
Angela M Neal-BarnettKent State University, Department of Psychological Sciences, 600 Hilltop Drive, Kent, OH 44242, USA. Electronic address: aneal@kent.edu.
Stephen M SaundersMarquette University, Department of Psychology, 317 Cramer Hall, Milwaukee, WI 53233, USA. Electronic address: stephen.saunders@marquette.edu.
Martin E FranklinUniversity of Pennsylvania School of Medicine, Department of Psychiatry, 3535 Market St., Philadelphia, PA 19104, USA. Electronic address: marty@mail.med.upenn.edu.
Douglas W WoodsTexas A&M University, Department of Psychology, 4235 TAMU, College Station, TX 77843, USA. Electronic address: dowoods@tamu.edu.

Funding

Acceptance Enhanced Behavior Therapy for TrichotillomaniaR01MH080966 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI WOODS, DOUGLAS W · 2009 to 2013
$1.8M
Alliance and Mechanisms of Medication Adherence in Pediatric Psychiatric PracticeF31MH094095 · NIMH · UNIVERSITY OF SOUTH FLORIDA · PI DE NADAI, ALESSANDRO STEVENS · 2013 to 2014
$69k
NIMH NIH HHS F31 MH094095NIMH NIH HHS F31MH094095NIMH NIH HHS R01 MH080966NIMH NIH HHS R01MH080966
6 · The paper itself

Abstract

The Massachusetts General Hospital Hairpulling Scale (MGH-HPS) and the NIMH Trichotillomania Severity Scale (NIMH-TSS) are two widely used measures of trichotillomania severity. Despite their popular use, currently no empirically-supported guidelines exist to determine the degrees of change on these scales that best indicate treatment response. Determination of such criteria could aid in clinical decision-making by defining clinically significant treatment response/recovery and producing accurate power analyses for use in clinical trials research. Adults with trichotillomania (N=69) participated in a randomized controlled trial of psychotherapy and were assessed before and after treatment. Response status was measured via the Clinical Global Impressions-Improvement Scale, and remission status was measured via the Clinical Global Impressions-Severity Scale. For treatment response, a 45% reduction or 7-point raw score change on the MGH-HPS was the best indicator of clinically significant treatment response, and on the NIMH-TSS, a 30-40% reduction or 6-point raw score difference was most effective cutoff. For disorder remission, a 55-60% reduction or 7-point raw score change on the MGH-HPS was the best predictor, and on the NIMH-TSS, a 65% reduction or 6-point raw score change was the best indicator of disorder remission. Implications of these findings are discussed.

Indexed as

Signal Detection, PsychologicalAdolescentAdultAgedBehavior TherapyFemaleHumansMaleMiddle AgedPatient Education as TopicPsychotherapyROC CurveTreatment OutcomeTrichotillomaniaYoung AdultHair pullingObsessive-compulsive disorderPsychotherapySignal detectionTrichotillomania

Identifiers

PMID26422605
PMCPMC4658278

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.