Trial reportPloS one2015
Patient-Provider Interactions Affect Symptoms in Gastroesophageal Reflux Disease: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01915173 (Response to Supplement and Placebo in GERD), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Response to Supplement and Placebo in GERD
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Placebo Economics: A Systematic Review About the Economic Potential of Utilizing the Placebo Effect.Frontiers in psychiatry · 2019Pooled it
- Randomised, double-blind, placebo-controlled trials of non-individualised homeopathic treatment: systematic review and meta-analysis.Systematic reviews · 2017Pooled it
- Improved health outcomes in integrative medicine visits may reflect differences in physician and patient behaviors compared to standard medical visits.Patient education and counseling · 2021Trial
- Influence of the patient-practitioner interaction context on acupuncture outcomes in functional dyspepsia: study protocol for a multicenter randomized controlled trial.BMC complementary and alternative medicine · 2017Trial
- What can be done to control the placebo response in clinical trials? A narrative review.Contemporary clinical trials · 2021Review
- Perceptions and experiences of a manual therapy trial: a qualitative study of people with moderate to severe COPD.Chiropractic & manual therapies · 2021Article
- Why did the sham-treated EPISOD study subjects do so well? Important lessons for research and practice.Gastrointestinal endoscopy · 2019Article
- Article
- Modeling Health Disparities and Outcomes in Disenfranchised Populations.Community mental health journal · 2019Article
- Placebo Effects in Traumatic Brain Injury.Journal of neurotrauma · 2018Review
- The Role of Social and Interpersonal Factors in Placebo Analgesia.International review of neurobiology · 2018Review
- Homeopathy Use by US Adults: Results of a National Survey.American journal of public health · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIt is unclear whether the benefits that some patients derive from complementary and integrative medicine (CIM) are related to the therapies recommended or to the consultation process as some CIM provider visits are more involved than conventional medical visits. Many patients with gastrointestinal conditions seek out CIM therapies, and prior work has demonstrated that the quality of the patient-provider interaction can improve health outcomes in irritable bowel syndrome, however, the impact of this interaction on gastroesophageal reflux disease (GERD) is unknown. We aimed to assess the safety and feasibility of conducting a 2 x 2 factorial design study preliminarily exploring the impact of the patient-provider interaction, and the effect of an over-the-counter homeopathic product, Acidil, on symptoms and health-related quality of life in subjects with GERD.
methods24 subjects with GERD-related symptoms were randomized in a 2 x 2 factorial design to receive 1) either a standard visit based on an empathic conventional primary care evaluation or an expanded visit with questions modeled after a CIM consultation and 2) either Acidil or placebo for two weeks. Subjects completed a daily GERD symptom diary and additional measures of symptom severity and health-related quality of life.
resultsThere was no significant difference in GERD symptom severity between the Acidil and placebo groups from baseline to follow-up (p = 0.41), however, subjects who received the expanded visit were significantly more likely to report a 50% or greater improvement in symptom severity compared to subjects who received the standard visit (p = 0.01). Total consultation length, perceived empathy, and baseline beliefs in CIM were not associated with treatment outcomes.
conclusionAn expanded patient-provider visit resulted in greater GERD symptom improvement than a standard empathic medical visit. CIM consultations may have enhanced placebo effects, and further studies to assess the active components of this visit-based intervention are warranted.
trial registrationClinicalTrials.gov NCT01915173.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.