Evidence map›Paper›PMID 26422415›Full record

Trial reportJournal of ethnicity in substance abuse

Racial differences in adherence and response to combined treatment for full and subthreshold post-traumatic stress disorder and alcohol use disorders: A secondary analysis.

Lesia M Ruglass, Annelisa Pedersen, Soumia Cheref, Mei-Chen Hu, Denise A Hien

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of ethnicity in substance abuse. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00262223 (Combined Treatment for Alcohol-Dependent Individuals With PTSD), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00262223 phase2completednot on this map

Combined Treatment for Alcohol-Dependent Individuals With PTSD

TypeinterventionalSponsorNew York State Psychiatric InstituteRan2006 to 2013Enrolled69ConditionsStress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related DisordersArmsSeeking Safety, Sertraline, Pill placebo
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Lesia M Ruglassa Department of Psychology , City College of New York of CUNY , New York , NY.
Annelisa Pedersena Department of Psychology , City College of New York of CUNY , New York , NY.
Soumia Cherefb Department of Psychology , University of Houston , Houston , TX.
Mei-Chen Huc Department of Psychiatry , Columbia University College of Physicians and Surgeons , New York , NY.
Denise A Hiend Gordon F. Derner Institute for Advanced Psychological Studies, Adelphi University and Department of Psychiatry , Columbia University College of Physicians and Surgeons , New York , NY.
City College of New York · USColumbia University · USUniversity of Houston · US

Funding

Combined Treatment of Alcohol-Dependent Women with PTSDR01AA014341 · NIAAA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI HIEN, DENISE AIMEE · 2005 to 2009
$3.2M
NIAAA NIH HHS R01 AA014341
6 · The paper itself

Abstract

We conducted a secondary data analysis to examine whether there were racial differences in adherence and treatment outcomes for participants with co-occurring full and subthreshold post-traumatic stress disorder (PTSD) and alcohol/substance use disorders (A/SUD) who were treated with Seeking Safety (a cognitive-behavioral therapy) and sertraline or Seeking Safety and placebo as part of a clinical trial. Bivarate analyses examined the association between race and adherence, and generalized estimating equations assessed whether race moderated the effect of combination treatment on PTSD and alcohol use outcomes. Except for education, there were no statistically significant racial differences in baseline demographic and psychiatric characteristics. African Americans and Caucasians were equally adherent in number of psychotherapy and medication sessions attended and medication compliance. After controlling for baseline demographics and psychiatric symptoms, however, a race by treatment condition interaction emerged suggesting that African Americans who received the Seeking Safety and sertraline treatment had significantly lower PTSD symptom severity posttreatment and at six months follow-up compared to their counterparts who received Seeking Safety and placebo. No differential effect of treatment condition was found for Caucasians. Moreover, results indicated that a diagnosis of major depressive disorder negatively impacted PTSD symptom recovery for African American participants but not for Caucasians. In conclusion, no differences emerged between African Americans and Caucasians in adherence to combination treatments for PTSD and A/SUD. Findings also suggest assessment and treatment of MDD among African Americans may improve treatment outcomes. More research is needed to determine whether the differential response to Seeking Safety and sertraline among African Americans compared to Caucasians can be replicated.

Indexed as

Major Depressive DisorderOutcome Assessment, Health CareAdultAlcohol-Related DisordersBlack or African AmericanCognitive Behavioral TherapyCombined Modality TherapyFemaleHumansMaleMiddle AgedPatient ComplianceSelective Serotonin Reuptake InhibitorsSertralineStress Disorders, Post-TraumaticWhite PeopleSelective Serotonin Reuptake InhibitorsSertralineAlcohol use disordersPTSDracial differencesseeking safetysertralinesubstance use disorders

Identifiers

PMID26422415
PMCPMC5581661
OpenAlexW2191911833

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.