Trial reportThe Laryngoscope2016
The effect of noninvasive brain stimulation on neural connectivity in Tinnitus: A randomized trial.
Trial report in The Laryngoscope, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03425045 (Repetitive Transcranial Magnetic Stimulation for Chronic Subjective Non-Pulsatile Primary Tinnitus Compared to Placebo and Medicament Therapy), which is not on this map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Repetitive Transcranial Magnetic Stimulation for Chronic Subjective Non-Pulsatile Primary Tinnitus Compared to Placebo and Medicament Therapy
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Repetitive transcranial magnetic stimulation on chronic tinnitus: a systematic review and meta-analysis.BMC psychiatry · 2020Pooled it
- Effects of repetitive transcranial magnetic stimulation on resting-state connectivity: A systematic review.NeuroImage · 2020Pooled it
- RTMS parameters in tinnitus trials: a systematic review.Scientific reports · 2019Pooled it
- Cognitive Training for Adults With Bothersome Tinnitus: A Randomized Clinical Trial.JAMA otolaryngology-- head & neck surgery · 2017Trial
- Current and Emerging Therapies for Chronic Subjective Tinnitus.Journal of clinical medicine · 2023Review
- The Evaluation of Effects of Electrical Stimulation in Treatment of Patients with Chronic Tinnitus with Normal Hearing Sensitivity.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Insight Into the Effects of Clinical Repetitive Transcranial Magnetic Stimulation on the Brain From Positron Emission Tomography and Magnetic Resonance Imaging Studies: A Narrative Review.Frontiers in neuroscience · 2022Review
- Implications of Transcranial Magnetic Stimulation as a Treatment Modality for Tinnitus.Journal of clinical medicine · 2021Review
- Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers.Journal of clinical medicine · 2021Review
- Altered functional connectivity of the thalamus in tinnitus patients is correlated with symptom alleviation after sound therapy.Brain imaging and behavior · 2020Article
- Combined transcranial magnetic stimulation in the treatment of chronic tinnitus.Annals of clinical and translational neurology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectives/hypothesisTo explore neural connectivity changes associated with repetitive transcranial magnetic stimulation (rTMS) to the temporoparietal junction for patients with bothersome tinnitus. STUDY
designRandomized, double-blind, controlled clinical trial.
methodsThirty patients with subjective, nonpulsatile tinnitus for 6 months duration or longer and a score of 36 or greater on the Tinnitus Handicap Inventory completed the study. Participants were randomized to receive either sham or active treatment with rTMS to the temporoparietal junction for either 2 or 4 weeks of therapy. Participants underwent resting state functional connectivity magnetic resonance imaging before therapy and immediately following treatment. Functional connectivity changes between active and sham treatment groups were compared using regions of interest in auditory, default mode, ventral attention, and executive attention networks.
resultsSixteen patients received active rTMS treatment; 14 patients received sham treatment. There were no differences between the active and sham groups in baseline functional connectivity. Neither treatment with rTMS nor sham therapy resulted in statistically significant functional connectivity changes in the examined brain networks.
conclusionsThe analysis did not identify any changes in neural connectivity following treatment in patients with bothersome tinnitus. These results are consistent with our findings of lack of symptom changes previously reported in the same group of patients. Measures of neural connectivity may inform future work using rTMS to better understand the possible benefits of neural stimulation for tinnitus. LEVEL OF EVIDENCE: 1b. Laryngoscope, 126:1201-1206, 2016.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.