ArticleLangmuir : the ACS journal of surfaces and colloids2015
pH Responsiveness of Multilayered Films and Membranes Made of Polysaccharides.
Article in Langmuir : the ACS journal of surfaces and colloids, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Delivery timing determines senomorphic efficacy: delayed local ruxolitinib restores macrophage polarization and rescues age-impaired bone repair.Research square · 2026Article
- Gelatin Adsorption onto Cellulose Nanocrystals Surfaces at Different pH: A QCM-D Study.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Advances of antimicrobial dressings loaded with antimicrobial agents in infected wounds.Frontiers in bioengineering and biotechnology · 2024Review
- Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications.Marine drugs · 2023Review
- Effects of Feed Solution pH on Polyelectrolyte Multilayer Nanofiltration Membranes.ACS applied polymer materials · 2023Article
- A new polysaccharide platform constructs self-adjuvant nanovaccines to enhance immune responses.Journal of nanobiotechnology · 2022Article
- Weak Polyelectrolytes as Nanoarchitectonic Design Tools for Functional Materials: A Review of Recent Achievements.Molecules (Basel, Switzerland) · 2022Review
- Polyelectrolyte Gels: Fundamentals, Fabrication and Applications.Gels (Basel, Switzerland) · 2021Review
- Polyelectrolyte Multilayer Films Based on Natural Polymers: From Fundamentals to Bio-Applications.Polymers · 2021Review
- Hysteretic Swelling/Deswelling of Polyelectrolyte Brushes and Bilayer Films in Response to Changes in pH and Salt Concentration.Polymers · 2021Article
- Voltammetric pH Measurements Using Azure A-Containing Layer-by-Layer Film Immobilized Electrodes.Polymers · 2020Article
- Layer-By-Layer Assemblies of Biopolymers: Build-Up, Mechanical Stability and Molecular Dynamics.Polymers · 2020Review
- Polyelectrolyte Multilayer Capsule (PEMC)-Based Scaffolds for Tissue Engineering.Micromachines · 2020Review
- Article
- Structural heterogeneity in polymeric nitric oxide donor nanoblended coatings for controlled release behaviors.RSC advances · 2018Article
- Cell Type Influences Local Delivery of Biomolecules from a Bioinspired Apatite Drug Delivery System.Materials (Basel, Switzerland) · 2018Article
- Sequentially Moldable and Bondable Four-Dimensional Hydrogels Compatible with Cell Encapsulation.Biomacromolecules · 2018Article
- Preparation of Well-Dispersed Chitosan/Alginate Hollow Multilayered Microcapsules for Enhanced Cellular Internalization.Molecules (Basel, Switzerland) · 2018Article
- Nacre-mimic Reinforced Ag@reduced Graphene Oxide-Sodium Alginate Composite Film for Wound Healing.Scientific reports · 2017Article
- Tuning cell adhesive properties via layer-by-layer assembly of chitosan and alginate.Acta biomaterialia · 2017Article
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Authors and funding
8 authors.
Funding
Abstract
We investigated the pH-dependent properties of multilayered films made of chitosan (CHI) and alginate (ALG) and focused on their postassembly response to different pH environments using a quartz crystal microbalance with dissipation monitoring (QCM-D), swelling studies, ζ potential measurements, and dynamic mechanical analysis (DMA). In an acidic environment, the multilayers presented lower dissipation values and, consequently, higher moduli when compared with the values obtained for the pH used during the assembly (5.5). When the multilayers were exposed to alkaline environments, the opposite behavior occurred. These results were further corroborated by the ability of this multilayered system to exhibit a reversible swelling-deswelling behavior within the pH range from 3 to 9. The changes in the physicochemical properties of the multilayer system were gradual and different from those of individual solubilized polyelectrolytes. This behavior is related to electrostatic interactions between the ionizable groups combined with hydrogen bonding and hydrophobic interactions. Beyond the pH range of 3-9, the multilayers were stabilized by genipin cross-linking. The multilayered films also became more rigid while the pH responsiveness conferred by the ionizable moieties of the polyelectrolytes was preserved. This work demonstrates the versatility and feasibility of LbL methodology to generate inherently pH stimulus-responsive nanostructured films. Surface functionalization using pH responsiveness endows several biomedical applications with abilities such as drug delivery, diagnostics, microfluidics, biosensing, and biomimetic implantable membranes.
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