ArticlePloS one2015
Acute Biphasic Effects of Ayahuasca.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The pharmacological interaction of compounds in ayahuasca: a systematic review.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Pooled it
- Pharmacokinetics of N,N-dimethyltryptamine in Humans.European journal of drug metabolism and pharmacokinetics · 2023Trial
- Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study.Translational psychiatry · 2022Trial
- LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion.Human brain mapping · 2016Trial
- LSD reconfigures cortical dynamics through faster brain rhythms and increased fractal dimension.Communications biology · 2026Article
- Overcoming Pharmacokinetic and Peripheral Safety Challenges in Psychedelic Therapies: The Promise of Advanced Drug Delivery Systems.ACS pharmacology & translational science · 2026Review
- Visual Hallucinations in Serotonergic Psychedelics and Lewy Body Diseases.Schizophrenia bulletin · 2025Review
- The evolution of N, N-Dimethyltryptamine: from metabolic pathways to brain connectivity.Psychopharmacology · 2025Review
- Psilocybin-induced modulation of visual salience processing.Neuroscience of consciousness · 2025Article
- A new insight into ayahuasca's adverse effects: Reanalysis and perspectives on its mediating role in mental health from the Global Ayahuasca Survey (GAS).PLOS mental health · 2025Article
- Neurobiological research on N,N-dimethyltryptamine (DMT) and its potentiation by monoamine oxidase (MAO) inhibition: from ayahuasca to synthetic combinations of DMT and MAO inhibitors.Cellular and molecular life sciences : CMLS · 2024Review
- Synthetic surprise as the foundation of the psychedelic experience.Neuroscience and biobehavioral reviews · 2024Review
- Psychedelic and nutraceutical interventions as therapeutic strategies for military-related mild traumatic brain injuries.Journal of military, veteran and family health · 2023Review
- Ayahuasca: A review of historical, pharmacological, and therapeutic aspects.PCN reports : psychiatry and clinical neurosciences · 2023Review
- A Systematic Review on the Therapeutic Effects of Ayahuasca.Plants (Basel, Switzerland) · 2023Review
- Awake or Sleeping? Maybe Both… A Review of Sleep-Related Dissociative States.Journal of clinical medicine · 2023Review
- N,N-dimethyltryptamine affects electroencephalography response in a concentration-dependent manner-A pharmacokinetic/pharmacodynamic analysis.CPT: pharmacometrics & systems pharmacology · 2023Article
- Underlying pharmacological mechanisms of psilocin-induced broadband desynchronization and disconnection of EEG in rats.Frontiers in neuroscience · 2023Article
- The Altered States Database: Psychometric data from a systematic literature review.Scientific data · 2022Article
- Understanding brain states across spacetime informed by whole-brain modelling.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ritual use of ayahuasca, an amazonian Amerindian medicine turned sacrament in syncretic religions in Brazil, is rapidly growing around the world. Because of this internationalization, a comprehensive understanding of the pharmacological mechanisms of action of the brew and the neural correlates of the modified states of consciousness it induces is important. Employing a combination of electroencephalogram (EEG) recordings and quantification of ayahuasca's compounds and their metabolites in the systemic circulation we found ayahuasca to induce a biphasic effect in the brain. This effect was composed of reduced power in the alpha band (8-13 Hz) after 50 minutes from ingestion of the brew and increased slow- and fast-gamma power (30-50 and 50-100 Hz, respectively) between 75 and 125 minutes. Alpha power reductions were mostly located at left parieto-occipital cortex, slow-gamma power increase was observed at left centro-parieto-occipital, left fronto-temporal and right frontal cortices while fast-gamma increases were significant at left centro-parieto-occipital, left fronto-temporal, right frontal and right parieto-occipital cortices. These effects were significantly associated with circulating levels of ayahuasca's chemical compounds, mostly N,N-dimethyltryptamine (DMT), harmine, harmaline and tetrahydroharmine and some of their metabolites. An interpretation based on a cognitive and emotional framework relevant to the ritual use of ayahuasca, as well as it's potential therapeutic effects is offered.
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