Evidence map›Paper›PMID 26421677›Full record

SynthesisThe Cochrane database of systematic reviews2015

Buprenorphine for neuropathic pain in adults.

Philip J Wiffen, Sheena Derry, R Andrew Moore, Cathy Stannard, Dominic Aldington, Peter Cole, Roger Knaggs

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Cochrane database of systematic reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 12 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 12 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pregabalin for neuropathic pain in adults.The Cochrane database of systematic reviews · 2019
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Drug therapy for chronic idiopathic axonal polyneuropathy.The Cochrane database of systematic reviews · 2017
    Pooled it
  8. Gabapentin for chronic neuropathic pain in adults.The Cochrane database of systematic reviews · 2017
    Pooled it
  9. Morphine for chronic neuropathic pain in adults.The Cochrane database of systematic reviews · 2017
    Pooled it
  10. Pooled it
  11. Fentanyl for neuropathic pain in adults.The Cochrane database of systematic reviews · 2016
    Pooled it
  12. Hydromorphone for neuropathic pain in adults.The Cochrane database of systematic reviews · 2016
    Pooled it
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Philip J WiffenPain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, UK, OX3 7LE.
Sheena Derry
R Andrew Moore
Cathy Stannard
Dominic Aldington
Peter Cole
Roger Knaggs
University of Oxford · GBGloucestershire Health and Care NHS Foundation Trust · GBOxford University Hospitals NHS Trust · GBRoyal Hampshire County Hospital · GBThame Community Hospital · GBUniversity of Nottingham · GB

Funding

Department of Health 13/89/29
6 · The paper itself

Abstract

backgroundOpioid drugs, including buprenorphine, are commonly used to treat neuropathic pain, and are considered effective by some professionals. Most reviews have examined all opioids together. This review sought evidence specifically for buprenorphine, at any dose, and by any route of administration. Other opioids are considered in separate reviews.

objectivesTo assess the analgesic efficacy of buprenorphine for chronic neuropathic pain in adults, and the adverse events associated with its use in clinical trials. SEARCH

methodsWe searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and EMBASE from inception to 11 June 2015, together with reference lists of retrieved papers and reviews, and two online study registries. SELECTION CRITERIA: We included randomised, double-blind studies of two weeks' duration or longer, comparing any oral dose or formulation of buprenorphine with placebo or another active treatment in chronic neuropathic pain. DATA COLLECTION AND ANALYSIS: Two review authors independently searched for studies, extracted efficacy and adverse event data, and examined issues of study quality. We did not carry out any pooled analyses. MAIN

resultsSearches identified 10 published studies, and one study with results in ClinicalTrials.gov. None of these 11 studies satisfied our inclusion criteria, and so we included no studies in the review. AUTHORS'

conclusionsThere was insufficient evidence to support or refute the suggestion that buprenorphine has any efficacy in any neuropathic pain condition.

Indexed as

AdultAnalgesics, OpioidBuprenorphineHumansNeuralgiaAnalgesics, OpioidBuprenorphine

Identifiers

PMID26421677
PMCPMC6481375
OpenAlexW2145978455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.