ArticleBioMed research international2015
Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population.Alzheimer's research & therapy · 2021Pooled it
- Whole-genome sequencing reveals the impact of lipid pathway and APOE genotype on brain amyloidosis.Human molecular genetics · 2025Article
- CYP1B1-RMDN2 Alzheimer's disease endophenotype locus identified for cerebral tau PET.Nature communications · 2024Article
- Genome-wide epistasis analysis reveals gene-gene interaction network on an intermediate endophenotype P-tau/AβScientific reports · 2024Article
- Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease.Acta neuropathologica communications · 2023Article
- Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's disease related proteins.Molecular neurodegeneration · 2023Article
- Clinical effects of novel susceptibility genes for beta-amyloid: a gene-based association study in the Korean population.Frontiers in aging neuroscience · 2023Article
- Multivariate genome wide association and network analysis of subcortical imaging phenotypes in Alzheimer's disease.BMC genomics · 2020Article
- Morbigenous brain region and gene detection with a genetically evolved random neural network cluster approach in late mild cognitive impairment.Bioinformatics (Oxford, England) · 2020Article
- A Novel Three-Stage Framework for Association Analysis Between SNPs and Brain Regions.Frontiers in genetics · 2020Article
- Quantitative Trait Module-Based Genetic Analysis of Alzheimer's Disease.International journal of molecular sciences · 2019Article
- Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.Scientific reports · 2019Article
- Latent Representation Learning for Alzheimer's Disease Diagnosis With Incomplete Multi-Modality Neuroimaging and Genetic Data.IEEE transactions on medical imaging · 2019Article
- A decade in psychiatric GWAS research.Molecular psychiatry · 2019Review
- Genome-wide Network-assisted Association and Enrichment Study of Amyloid Imaging Phenotype in Alzheimer's Disease.Current Alzheimer research · 2019Article
- Biothiols and oxidative stress markers and polymorphisms ofOncotarget · 2018Article
- Identification of genome-wide SNP-SNP interactions associated with important traits in chicken.BMC genomics · 2017Article
- Genome-wide association and interaction studies of CSF T-tau/AβNeurobiology of aging · 2017Article
- Genome-wide network-based pathway analysis of CSF t-tau/Aβ1-42 ratio in the ADNI cohort.BMC genomics · 2017Article
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10 authors.
Funding
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disorder. Using discrete disease status as the phenotype and computing statistics at the single marker level may not be able to address the underlying biological interactions that contribute to disease mechanism and may contribute to the issue of "missing heritability." We performed a genome-wide association study (GWAS) and a genome-wide interaction study (GWIS) of an amyloid imaging phenotype, using the data from Alzheimer's Disease Neuroimaging Initiative. We investigated the genetic main effects and interaction effects on cingulate amyloid-beta (Aβ) load in an effort to better understand the genetic etiology of Aβ deposition that is a widely studied AD biomarker. PLINK was used in the single marker GWAS, and INTERSNP was used to perform the two-marker GWIS, focusing only on SNPs with p ≤ 0.01 for the GWAS analysis. Age, sex, and diagnosis were used as covariates in both analyses. Corrected p values using the Bonferroni method were reported. The GWAS analysis revealed significant hits within or proximal to APOE, APOC1, and TOMM40 genes, which were previously implicated in AD. The GWIS analysis yielded 8 novel SNP-SNP interaction findings that warrant replication and further investigation.
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