Evidence map›Paper›PMID 26421279›Full record

ArticleBioMed research international2015

A Population-Based Model to Consider the Effect of Seasonal Variation on Serum 25(OH)D and Vitamin D Status.

Philippe Vuistiner, Valentin Rousson, Hugues Henry, Pierre Lescuyer, Olivier Boulat, Jean-Michel Gaspoz, Vincent Mooser, Peter Vollenweider, Gerard Waeber, Jacques Cornuz and 3 more

Abstract read
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Philippe VuistinerInstitute of Social and Preventive Medicine (IUMSP), University Hospital of Lausanne (CHUV), 1010 Lausanne, Switzerland.
Valentin RoussonInstitute of Social and Preventive Medicine (IUMSP), University Hospital of Lausanne (CHUV), 1010 Lausanne, Switzerland.
Hugues HenryBiomedicine, University Hospital of Lausanne, 1011 Lausanne, Switzerland.
Pierre LescuyerDepartment of Genetic and Laboratory Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.
Olivier BoulatBiomedicine, University Hospital of Lausanne, 1011 Lausanne, Switzerland.
Jean-Michel GaspozUnit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.
Vincent MooserBiomedicine, University Hospital of Lausanne, 1011 Lausanne, Switzerland.
Peter VollenweiderDepartment of Internal Medicine, Internal Medicine, University Hospital of Lausanne (CHUV), 1011 Lausanne, Switzerland.
Gerard WaeberDepartment of Internal Medicine, Internal Medicine, University Hospital of Lausanne (CHUV), 1011 Lausanne, Switzerland.
Jacques CornuzDepartment for Ambulatory Care and Community Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
Fred PaccaudInstitute of Social and Preventive Medicine (IUMSP), University Hospital of Lausanne (CHUV), 1010 Lausanne, Switzerland.
Murielle BochudInstitute of Social and Preventive Medicine (IUMSP), University Hospital of Lausanne (CHUV), 1010 Lausanne, Switzerland.
Idris GuessousInstitute of Social and Preventive Medicine (IUMSP), University Hospital of Lausanne (CHUV), 1010 Lausanne, Switzerland ; Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland ; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe elaborated a model that predicts the centiles of the 25(OH)D distribution taking into account seasonal variation.

methodsData from two Swiss population-based studies were used to generate (CoLaus) and validate (Bus Santé) the model. Serum 25(OH)D was measured by ultra high pressure LC-MS/MS and immunoassay. Linear regression models on square-root transformed 25(OH)D values were used to predict centiles of the 25(OH)D distribution. Distribution functions of the observations from the replication set predicted with the model were inspected to assess replication.

resultsOverall, 4,912 and 2,537 Caucasians were included in original and replication sets, respectively. Mean (SD) 25(OH)D, age, BMI, and % of men were 47.5 (22.1) nmol/L, 49.8 (8.5) years, 25.6 (4.1) kg/m(2), and 49.3% in the original study. The best model included gender, BMI, and sin-cos functions of measurement day. Sex- and BMI-specific 25(OH)D centile curves as a function of measurement date were generated. The model estimates any centile of the 25(OH)D distribution for given values of sex, BMI, and date and the quantile corresponding to a 25(OH)D measurement.

conclusionsWe generated and validated centile curves of 25(OH)D in the general adult Caucasian population. These curves can help rank vitamin D centile independently of when 25(OH)D is measured.

Indexed as

Models, BiologicalSeasonsAdultAgedBody Mass IndexHumansMiddle AgedReproducibility of ResultsVitamin D25-hydroxyvitamin DVitamin D

Identifiers

PMID26421279
PMCPMC4569755

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.