Evidence map›Paper›PMID 26421209›Full record

ArticleParkinson's disease2015

MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson's Disease.

Ilana Schlesinger, Ayelet Eran, Alon Sinai, Ilana Erikh, Maria Nassar, Dorith Goldsher, Menashe Zaaroor

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinson's disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 6 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 6 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Pooled it
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  5. Clinical application of magnetic resonance-guided focused ultrasound in Parkinson's disease: a meta-analysis of randomized clinical trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Pooled it
  6. Pooled it
  7. Review
  8. Focused ultrasound therapy for neurological disease.Journal of medical ultrasonics (2001) · 2026
    Review
  9. Article
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  13. Article
  14. Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ilana SchlesingerDepartment of Neurology, Rambam Health Care Campus, Haifa, Israel ; Technion Faculty of Medicine, Haifa, Israel.
Ayelet EranDepartment of Radiology, Rambam Health Care Campus, Haifa, Israel.
Alon SinaiDepartment of Neurology, Rambam Health Care Campus, Haifa, Israel ; Department of Neurosurgery, Rambam Health Care Campus, Haifa, Israel.
Ilana ErikhDepartment of Neurology, Rambam Health Care Campus, Haifa, Israel.
Maria NassarDepartment of Neurology, Rambam Health Care Campus, Haifa, Israel.
Dorith GoldsherTechnion Faculty of Medicine, Haifa, Israel ; Department of Radiology, Rambam Health Care Campus, Haifa, Israel.
Menashe ZaaroorTechnion Faculty of Medicine, Haifa, Israel ; Department of Neurosurgery, Rambam Health Care Campus, Haifa, Israel.
Rambam Health Care Campus · ILTechnion – Israel Institute of Technology · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background. Thalamotomy is effective in alleviating tremor in Parkinson's disease (PD). Methods. Seven PD patients, mean age 59.4 ± 9.8 years (range, 46-74) with a mean disease duration of 5.4 ± 2.8 years (range, 2-10) suffering from severe refractory tremor, underwent ventral intermediate nucleus thalamotomy using MRI guided focused ultrasound (MRgFUS), an innovative technology that enables noninvasive surgery. Results. Tremor stopped in the contralateral upper extremity in all patients immediately following treatment. Total UPDRS decreased from 37.4 ± 12.2 to 18.8 ± 11.1 (p = 0.007) and PDQ-39 decreased from 42.3 ± 16.4 to 21.6 ± 10.8 (p = 0.008) following MRgFUS. These effects were sustained (mean follow-up 7.3 months). Adverse events during MRgFUS included headache (n = 3), dizziness (n = 2), vertigo (n = 4), and lip paresthesia (n = 1) and following MRgFUS were hypogeusia (n = 1), unsteady feeling when walking (n = 1, resolved), and disturbance when walking tandem (n = 1, resolved). Conclusions. Thalamotomy using MRgFUS is safe and effective in PD patients. Large randomized studies are needed to assess prolonged efficacy and safety.

Identifiers

PMID26421209
PMCPMC4572440
OpenAlexW1740955462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.