Evidence map›Paper›PMID 26421175›Full record

ArticleIranian Red Crescent medical journal2015

No Evidence for Association Between Norepinephrine Transporter-3081 (A/T) Polymorphism and Attention Deficit Hyperactivity Disorder in Iranian Population.

Mohammad Reza Eslami Amirabadi, Rozita Davari-Ashtiani, Mojgan Khademi, Sepideh RajeziEsfahani, Babak Emamalizadeh, Abolfazl Movafagh, Fariba Arabgol, Said Sadr, Hossein Darvish, Katayoon Razjouyan

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Article in Iranian Red Crescent medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 10 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Mohammad Reza Eslami AmirabadiBehavioral Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Rozita Davari-AshtianiDepartment of Psychiatry, Imam Hosein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Mojgan KhademiDepartment of Psychiatry, Imam Hosein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Sepideh RajeziEsfahaniBehavioral Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Babak EmamalizadehDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Abolfazl MovafaghDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Fariba ArabgolDepartment of Psychiatry, Imam Hosein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Said SadrDepartment of Psychiatry, Imam Hosein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Hossein DarvishDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Katayoon RazjouyanDepartment of Psychiatry, Imam Hosein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Shahid Beheshti University of Medical Sciences · IRImam Hossein Hospital · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAttention Deficit Hyperactivity Disorder (ADHD) can lead to drastic problems for the patient and its worldwide prevalence is 5%-12%. It also has many comorbidities with other disorders, and the genetic contribution seems the most significant cause.

objectivesThe current study was conducted to investigate the association between norepinephrine transporter-3081 (A/T) polymorphisms and ADHD in Iranian population. PATIENTS AND

methodsParticipants were chosen from children and adolescents diagnosed with ADHD referred to Imam Hoseyn Hospital. A child and adolescent psychiatrist confirmed the diagnosis using the Kiddie-Sads-Present and Lifetime Version (K-SADS-PL) semi-structural interview. The control group was from pupils of schools in Tehran (capital city of Iran) who had no history or presence of psychiatric and medical complications. Also, a child and adolescent psychiatrist confirmed their health using the K-SADS-PL semi-structural interview. Genetic examinations were DNA distraction, Polymerase Chain Reaction (PCR), and Restricted Fragment Length Polymorphism (RFLP), which were conducted according to standard protocols. The statistical analysis was performed using chi-square and Fisher's exact test in SPSS version 21.

resultsThe percentages of ADHD subtypes for combined, inattentive, and hyperactive/impulsive were 72.2%, 17.2%, and 11.9%, respectively. There was no significant association between norepinephrine transporter polymorphism and ADHD (P = 0.81). Moreover, no significant relationship was found between gender [male (P = 0.92) and female (P = 0.63)] and polymorphism. No significant association was found between subtypes of ADHD [combined (P = 0.46), inattentive (P = 0.41), hyperactive/impulsive (P = 0.32)] and polymorphism SCL6A2. This lack of association can also be seen in gender in every subtype.

conclusionsThe results of the study show no significant association between norepinephrine transporter polymorphism SCL6A2 and ADHD.

Indexed as

Attention Deficit Disorder with HyperactivityHumansIranPolymorphism, GeneticSCL6A2 Protein

Identifiers

PMID26421175
PMCPMC4584105
OpenAlexW1783823248

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