ReviewThe journal of physiological sciences : JPS2015
Frontier studies on fatigue, autonomic nerve dysfunction, and sleep-rhythm disorder.
Review in The journal of physiological sciences : JPS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fatigue Monitoring Through Wearables: A State-of-the-Art Review.Frontiers in physiology · 2021Pooled it
- Far-infrared stimulation of Neiguan acupoints improves heart rate variability and ameliorate fatigue in hemodialysis patients: A randomized trial.Journal of the Chinese Medical Association : JCMA · 2024Trial
- Trial
- Anti-Fatigue Effects of Yogurt Fermented withNutrients · 2018Trial
- Randomized Pilot Trial Using External Yarrow Liver Compress Applications With Metastatic Cancer Patients Suffering From Fatigue: Evaluation of Sympathetic Modulation by Heart Rate Variability Analysis.Integrative cancer therapiesTrial
- Association between light exposure patterns and multidimensional health outcomes in individuals with myalgic encephalomyelitis/chronic fatigue syndrome: findings from an observational cross-sectional cohort study.Journal of translational medicine · 2026Observational
- Associated factors and assessment of clinical symptoms including fatigue, insomnia, and gastrointestinal discomfort of chronic fatigue syndrome: a cross-sectional case-control study.Journal of translational medicine · 2026Article
- Sympathetic skin response in fibromyalgia patients with small fibre pathology.Clinical neurophysiology practice · 2026Article
- Associations between multidimensional fatigue and wearable-derived cardio-respiratory variables in post-COVID-19 patients: an observational study.Frontiers in digital health · 2026Article
- Tiredness/fatigue and sexuality in everyday life: Findings from an ecological momentary assessment.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Somatic symptoms among young adults: an observational study examining the roles of trauma type and psychological distress.BMC psychology · 2025Observational
- Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms.Journal of personalized medicine · 2025Review
- Estimating psychophysiological loads by repeated temperature steps on humans using a state-space model.PloS one · 2025Article
- Yoga for psychological outcomes and quality of life in non-cystic fibrosis bronchiectasis: a controlled study.Frontiers in psychiatry · 2025Article
- Acoustic-based machine learning approaches for depression detection in Chinese university students.Frontiers in public health · 2025Article
- Review
- Inverse association between arterial stiffness and perceived fatigue independent of disability status and BMI in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Relationships between physical fitness and match running demands during a futsal congested-weeks training camp.Biology of sport · 2024Article
- Article
- A network analysis of the interrelationships between depression, anxiety, insomnia and quality of life among fire service recruits.Frontiers in public health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatigue is defined as a condition or phenomenon of decreased ability and efficiency of mental and/or physical activities, caused by excessive mental or physical activities, diseases, or syndromes. It is often accompanied by a peculiar sense of discomfort, a desire to rest, and reduced motivation, referred to as fatigue sensation. Acute fatigue is a normal condition or phenomenon that disappears after a period of rest; in contrast, chronic fatigue, lasting at least 6 months, does not disappear after ordinary rest. Chronic fatigue impairs activities and contributes to various medical conditions, such as cardiovascular disease, epileptic seizures, and death. In addition, many people complain of chronic fatigue. For example, in Japan, more than one third of the general adult population complains of chronic fatigue. It would thus be of great value to clarify the mechanisms underlying chronic fatigue and to develop efficient treatment methods to overcome it. Here, we review data primarily from behavioral, electrophysiological, and neuroimaging experiments related to neural dysfunction as well as autonomic nervous system, sleep, and circadian rhythm disorders in fatigue. These data provide new perspectives on the mechanisms underlying chronic fatigue and on overcoming it.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.