Evidence map›Paper›PMID 26420461›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2015

Correlation between Echo-Tracking Parameters and In Vitro Measurements of Arterial Contraction and Relaxation in Rats Fed a High-Cholesterol Diet.

Yi Zhang, Wei-Wei Zhan, Yong-Jie Wu, Bo Zhao, Wu-Gang Zhou, Dong-Rui Chen, Wei Zhou, Zhen-Hua Liu, Wei-Min Jiang, Lin Zheng

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yi ZhangDepartment of Ultrasound, Rui Jin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China (mainland).
Wei-Wei ZhanDepartment of Ultrasound, Rui Jin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China (mainland).
Yong-Jie WuShanghai Institute of Hypertension, Ruijin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China (mainland).
Bo ZhaoDepartment of Ultrasound, Rui Jin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China (mainland).
Wu-Gang ZhouShanghai Institute of Hypertension, Ruijin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China (mainland).
Dong-Rui ChenShanghai Institute of Hypertension, Ruijin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China (mainland).
Wei ZhouDepartment of Ultrasound, Ruijin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China (mainland).
Zhen-Hua LiuDepartment of Ultrasound, Ruijin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China (mainland).
Wei-Min JiangDepartment of Pathology, School of Medicine, Shanghai JiaoTong University, Shanghai, China (mainland).
Lin ZhengDepartment of Pathology, School of Medicine, Shanghai JiaoTong University, Shanghai, China (mainland).
Shanghai Jiao Tong University · CNRuijin Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEcho-tracking (ET) is a new technique that allows the assessment of arterial function and stiffness. This study aimed to ascertain the utility of the echo-tracking (ET) technique to assess vascular stiffness in rats with hypercholesterolemia and atherosclerosis. MATERIAL AND

methodsET was used to measure the arterial stiffness of the aorta in cholesterol-fed Sprague-Dawley rats (group T1, n=10, for 4 weeks; group T2, n=10, for 12 weeks) and normal control rats (group C1, n=10; group C2, n=10). In vitro isometric tension experiments were used to measure the maximum contractile tension (MCT) and maximum relaxation percentage (MRR%) of aortic rings. Indicators of arterial stiffness and aortic MCT and MRR% were compared between groups using linear regression analysis. Light microscopic evaluation was used to demonstrate atherosclerotic changes in the aorta.

resultsThe rat models were successfully induced; pathological examination of the aortas showed significant atherosclerosis in group T2, but not in groups C1, C2, or T1. The arterial stiffness parameters obtained using ET and aortic rings in vitro showed significant impairments in T1 and T2 rats compared with C1 and C2 controls (all P<0.05 vs. controls). In addition, these impairments were greater in the T2 group than in the T1 group (all P<0.05). Finally, MRR% correlated with the distensibility coefficient (r=0.396, P=0.012), arterial compliance (r=0.317, P=0.047), stiffness parameter b (r=-0.406, P=0.009) and one-point pulse wave β (r=-0.434, P=0.005).

conclusionsThese results suggest that ET could be used to evaluate the changes in arterial wall elasticity associated with atherosclerosis and hypercholesterolemia.

Indexed as

DietVascular StiffnessAnimalsAortaAorta, AbdominalArteriesAtherosclerosisBlood PressureCholesterolElasticityEndothelium, VascularHypercholesterolemiaMaleRatsRats, Sprague-DawleyTreatment OutcomeCholesterol

Identifiers

PMID26420461
PMCPMC4596455
OpenAlexW2211664079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.