Evidence map›Paper›PMID 26420269›Full record

Trial reportTrials2015

Neurostimulation for cognitive rehabilitation in stroke (NeuroCog): study protocol for a randomized controlled trial.

Suellen Marinho Andrade, Bernardino Fernández-Calvo, Paulo Sérgio Boggio, Eliane Araújo de Oliveira, Lilze Franklim Gomes, José Eudes Gomes Pinheiro Júnior, Rafaela Martins Rodrigues, Natália Leandro de Almeida, Gioconda Marla de Siqueira Moreira, Nelson Torro Alves

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Trials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02315807 (Neurostimulation for Cognitive Enhancement After Stroke), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02315807 phase2 / phase3unknown statusnot on this map

Neurostimulation for Cognitive Enhancement After Stroke (NeuroCog)

TypeinterventionalSponsorFederal University of ParaíbaRan2015 to 2016Enrolled60ConditionsStroke, Cognitive Impairment, Cerebral InfarctionArmstranscranial direct current stimulation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Suellen Marinho AndradeCognitive Neuroscience and Behavior Program, Department of Psychology, Federal University of Paraíba, João Pessoa, Brazil. suellenandrade@gmail.com.
Bernardino Fernández-CalvoCognitive Neuroscience and Behavior Program, Department of Psychology, Federal University of Paraíba, João Pessoa, Brazil. bfcalvo@usal.es.
Paulo Sérgio BoggioCognitive Neuroscience Laboratory and Developmental Disorders Program, Mackenzie Presbyterian University, São Paulo, SP, Brazil. psboggio@gmail.com.
Eliane Araújo de OliveiraCenter for Research in Human Movement Sciences, Federal University of Paraíba, João Pessoa, PB, Brazil. elianeao@gmail.com.
Lilze Franklim GomesPerception, Neurosciences and Behavior Laboratory, Federal University of Paraíba, João Pessoa, PB, Brazil. lilzeffg@yahoo.com.br.
José Eudes Gomes Pinheiro JúniorDepartment of Sciences of Religions, NOUS Group, Federal University of Paraíbas, João Pessoa, PB, Brazil. juninho_eudes@hotmail.com.
Rafaela Martins RodriguesPerception, Neurosciences and Behavior Laboratory, Federal University of Paraíba, João Pessoa, PB, Brazil. rafaela.estagiaria@hotmail.com.
Natália Leandro de AlmeidaPerception, Neurosciences and Behavior Laboratory, Federal University of Paraíba, João Pessoa, PB, Brazil. natalialalmeida@hotmail.com.
Gioconda Marla de Siqueira MoreiraPerception, Neurosciences and Behavior Laboratory, Federal University of Paraíba, João Pessoa, PB, Brazil. giocondasiqueira@gmail.com.
Nelson Torro AlvesCognitive Neuroscience and Behavior Program, Department of Psychology, Federal University of Paraíba, João Pessoa, Brazil. nelsontorro@yahoo.com.br.
Universidade Federal da Paraíba · BRUniversidade Presbiteriana Mackenzie · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStroke patients may present severe cognitive impairments, primarily related to executive functions. Transcranial direct current stimulation has shown promising results, with neuromodulatory and neuroplastic effects. This study is a double-blind, sham-controlled clinical trial aiming to compare the long-term effects of stimulation in two different cognitive regions after a stroke. METHODS/

designSixty patients who suffer from chronic strokes will be randomized into one of four groups: dorsolateral prefrontal cortex, cingulo-opercular network, motor primary cortex and sham stimulation. Each group will receive transcranial direct current stimulation at an intensity of 2 mA for 20 minutes daily for 10 consecutive days. Patients will be assessed with a Dysexecutive Questionnaire, Semantic Fluency Test, categorical verbal fluency and Go-no go tests, Wechsler Adult Intelligence Scale, Rey Auditory-Verbal Learning Test, Letter Comparison and Pattern Comparison Tasks at baseline and after their tenth stimulation session. Those who achieve clinical improvement with neurostimulation will be invited to receive treatment for 12 months as part of a follow-up study. DISCUSSION: Long-term stimulation could be analyzed in regard to possible adaptive changes on plasticity after structural brain damage and if these changes are different in terms of clinical improvement when applied to two important cognitive centers. TRIALS REGISTRATION: Clinicaltrials.gov, NCT02315807 . 9 December 2014.

Indexed as

CognitionStroke RehabilitationAdolescentAdultBrazilCerebral CortexClinical ProtocolsCognition DisordersDouble-Blind MethodFemaleHumansMaleMiddle AgedNeuropsychological TestsRecovery of FunctionResearch Design

Identifiers

PMID26420269
PMCPMC4589066
OpenAlexW1859752227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.