ArticleBiology direct2015
Pan-genomic analysis to redefine species and subspecies based on quantum discontinuous variation: the Klebsiella paradigm.
Article in Biology direct, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
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- Whole-genome sequencing revealsMicrobial genomics · 2025Article
- Whole Genome Analyses Accurately IdentifyInternational journal of molecular sciences · 2022Article
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- Whole Genome Sequencing Based Taxonomic Classification, and Comparative Genomic Analysis of Potentially Human PathogenicMicroorganisms · 2021Article
- The Changing Face of the FamilyClinical microbiology reviews · 2021Review
- Identification and Monitoring ofJournal of microbiology and biotechnology · 2021Article
- Distinctive features gleaned from the comparative genomes analysis of clinical and non-clinical isolates of Klebsiella pneumoniae.Bioinformation · 2020Article
- Genome and pan-genome analysis to classify emerging bacteria.Biology direct · 2019Review
- A First Study of the Virulence Potential of aFrontiers in cellular and infection microbiology · 2019Article
- Gene Transmission in the One Health Microbiosphere and the Channels of Antimicrobial Resistance.Frontiers in microbiology · 2019Review
- Comparative genome analysis provides deep insights into Aeromonas hydrophila taxonomy and virulence-related factors.BMC genomics · 2018Article
- GET_PHYLOMARKERS, a Software Package to Select Optimal Orthologous Clusters for Phylogenomics and Inferring Pan-Genome Phylogenies, Used for a Critical Geno-Taxonomic Revision of the GenusFrontiers in microbiology · 2018Article
- Pan-genomic and transcriptomic analyses of Leuconostoc mesenteroides provide insights into its genomic and metabolic features and roles in kimchi fermentation.Scientific reports · 2017Article
- Article
- Epidemiological characteristics of Klebsiella ozaenae infection and its antibiotic susceptibility: Experience of a tertiary care hospital in the Eastern Province of Saudi Arabia.Journal of family & community medicineArticle
- Advanced prokaryotic systematics: the modern face of an ancient science.New microbes and new infectionsArticle
- Phenotypic and genotypic characteristics of carbapenemase- and extended spectrum β-lactamase-producingTherapeutic advances in infectious diseaseArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVarious methods are currently used to define species and are based on the phylogenetic marker 16S ribosomal RNA gene sequence, DNA-DNA hybridization and DNA GC content. However, these are restricted genetic tools and showed significant limitations.
resultsIn this work, we describe an alternative method to build taxonomy by analyzing the pan-genome composition of different species of the Klebsiella genus. Klebsiella species are Gram-negative bacilli belonging to the large Enterobacteriaceae family. Interestingly, when comparing the core/pan-genome ratio; we found a clear discontinuous variation that can define a new species.
conclusionsUsing this pan-genomic approach, we showed that Klebsiella pneumoniae subsp. ozaenae and Klebsiella pneumoniae subsp. rhinoscleromatis are species of the Klebsiella genus, rather than subspecies of Klebsiella pneumoniae. This pan-genomic analysis, helped to develop a new tool for defining species introducing a quantic perspective for taxonomy.
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