Trial reportLasers in medical science2015
Does addition of low-level laser therapy (LLLT) in conservative care of knee arthritis successfully postpone the need for joint replacement?
Trial report in Lasers in medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06122116 (Investigating Orthobiologics After Platelet-Rich Plasma and Photobiomodulation Treatment of Knee Osteoarthritis), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Orthobiologics After Platelet-Rich Plasma and Photobiomodulation Treatment of Knee Osteoarthritis
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adjunctive therapies in addition to land-based exercise therapy for osteoarthritis of the hip or knee.The Cochrane database of systematic reviews · 2022Pooled it
- Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- The Mechanisms and Efficacy of Photobiomodulation Therapy for Arthritis: A Comprehensive Review.International journal of molecular sciences · 2023Review
- Low-Level Laser Therapy for Rheumatoid Arthritis: A Review of Experimental Approaches.Journal of lasers in medical sciences · 2022Review
- Therapeutic application of light and electromagnetic fields to reduce hyper-inflammation triggered by COVID-19.Communicative & integrative biology · 2021Article
- Guidelines versus evidence: what we can learn from the Australian guideline for low-level laser therapy in knee osteoarthritis? A narrative review.Lasers in medical science · 2021Review
- Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19.Communicative & integrative biology · 2021Article
- Molecular and Cellular Mechanisms of Arthritis in Children and Adults: New Perspectives on Applied Photobiomodulation.International journal of molecular sciences · 2020Review
- Intra-Articular Laser Treatment Plus Platelet Rich Plasma (PRP) Significantly Reduces Pain in Many Patients Who Had Failed Prior PRP Treatment.Medicines (Basel, Switzerland) · 2019Article
- Interleukin-10 and collagen type II immunoexpression are modulated by photobiomodulation associated to aerobic and aquatic exercises in an experimental model of osteoarthritis.Lasers in medical science · 2018Article
- Treatment of Osteoarthritis With Low-level Laser Therapy, Acupuncture, and Herbal Therapy: A Case Report.Integrative medicine (Encinitas, Calif.) · 2018Article
- Mechanisms and applications of the anti-inflammatory effects of photobiomodulation.AIMS biophysics · 2017Article
- Use of electroanalgesia and laser therapies as alternatives to opioids for acute and chronic pain management.F1000Research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current study evaluates whether the addition of low-level laser therapy into standard conventional physical therapy in elderly with bilateral symptomatic tri-compartmental knee arthritis can successfully postpone the need for joint replacement surgery. A prospective randomized cohort study of 100 consecutive unselected elderly patients with bilateral symptomatic knee arthritis with each knee randomized to receive either treatment protocol A consisting of conventional physical therapy or protocol B which is the same as protocol A with added low-level laser therapy. The mean follow-up was 6 years. Treatment failure was defined as breakthrough pain which necessitated joint replacement surgery. After a follow-up of 6 years, patients clearly benefited from treatment with protocol B as only one knee needed joint replacement surgery, while nine patients treated with protocol A needed surgery (p < 0.05). We conclude low-level laser therapy should be incorporated into standard conservative treatment protocol for symptomatic knee arthritis.
Indexed as
Identifiers
26420240What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.