ArticleCancer research2015
Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors.
Article in Cancer research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 88 citations in OpenAlex.
- Quantitative Imaging of Pyruvate Metabolism in a Patient With Anaplastic Thyroid Cancer.Magnetic resonance in medicine · 2026Article
- Physiological Interpretation of the Lactate to Pyruvate AUC Ratio for Hyperpolarized [1-Magnetic resonance in medicine · 2026Article
- Optimized Detection of Left Ventricular Hyperpolarized [1-Magnetic resonance in medicine · 2026Article
- Pharmacokinetic modeling strategies for dynamic hyperpolarized urea imaging.Magnetic resonance in medicine · 2026Article
- Review
- Technologies and Strategies for Metabolic and Molecular Imaging With Hyperpolarized MRI.Journal of magnetic resonance imaging : JMRI · 2026Review
- Spatially constrained hyperpolarized 13C MRI pharmacokinetic rate constant map estimation using a digital brain phantom and a U-Net.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025Article
- Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025Review
- A pharmacokinetic model for hyperpolarizedMagnetic resonance in medicine · 2024Article
- Article
- Metabolic imaging across scales reveals distinct prostate cancer phenotypes.Nature communications · 2024Article
- First-in-Human Hyperpolarized MRI for Tumor Metabolism in HNSCC.JAMA otolaryngology-- head & neck surgery · 2024Article
- Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024Review
- Functional activation of pyruvate dehydrogenase in human brain using hyperpolarized [1-Magnetic resonance in medicine · 2024Article
- Hyperpolarized Carbon-13 Magnetic Resonance Imaging: Technical Considerations and Clinical Applications.Korean journal of radiology · 2024Review
- New Horizons in HyperpolarizedMolecular imaging and biology · 2024Article
- DynamicMagnetic resonance in medicine · 2024Article
- Moving from conventional to adaptive risk stratification for oropharyngeal cancer.Frontiers in oncology · 2024Review
- Mutual-information based optimal experimental design for hyperpolarized [Formula: see text]C-pyruvate MRI.Scientific reports · 2023Article
- A Simulation of the Effects of Diffusion on Hyperpolarized [1-IEEE transactions on bio-medical engineering · 2023Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 3 institutions in 1 country.
Funding
Abstract
Hyperpolarized [1-(13)C]-pyruvate has shown tremendous promise as an agent for imaging tumor metabolism with unprecedented sensitivity and specificity. Imaging hyperpolarized substrates by magnetic resonance is unlike traditional MRI because signals are highly transient and their spatial distribution varies continuously over their observable lifetime. Therefore, new imaging approaches are needed to ensure optimal measurement under these circumstances. Constrained reconstruction algorithms can integrate prior information, including biophysical models of the substrate/target interaction, to reduce the amount of data that is required for image analysis and reconstruction. In this study, we show that metabolic MRI with hyperpolarized pyruvate is biased by tumor perfusion and present a new pharmacokinetic model for hyperpolarized substrates that accounts for these effects. The suitability of this model is confirmed by statistical comparison with alternates using data from 55 dynamic spectroscopic measurements in normal animals and murine models of anaplastic thyroid cancer, glioblastoma, and triple-negative breast cancer. The kinetic model was then integrated into a constrained reconstruction algorithm and feasibility was tested using significantly undersampled imaging data from tumor-bearing animals. Compared with naïve image reconstruction, this approach requires far fewer signal-depleting excitations and focuses analysis and reconstruction on new information that is uniquely available from hyperpolarized pyruvate and its metabolites, thus improving the reproducibility and accuracy of metabolic imaging measurements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.