ArticleBMC microbiology2015
Deep sequencing analysis of transcriptomes in Aspergillus flavus in response to resveratrol.
Article in BMC microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Integrated transcriptomic and metabolomic analysis revealed the response of resistant variety Zhonghua 6 to the infection of Ralstonia solanacearum in peanut.BMC plant biology · 2026Article
- In Vitro Screening of the Antifungal and Antimycotoxin Effects of a Stilbenoids-Riche Grapevine Cane Extract onToxins · 2025Article
- Targeting Mitochondria to Inhibit Aflatoxin Production: Mechanistic Insight.Food safety (Tokyo, Japan) · 2025Article
- Inhibition Mechanism ofFoods (Basel, Switzerland) · 2025Article
- Article
- Transcriptomic and Proteomic Insights into the Effect of Sterigmatocystin onJournal of fungi (Basel, Switzerland) · 2023Article
- Modes-of-action of antifungal compounds: Stressors and (target-site-specific) toxins, toxicants, or toxin-stressors.Microbial biotechnology · 2023Review
- Non-thermal plasma induces changes in aflatoxin production, devitalization, and surface chemistry of Aspergillus parasiticus.Applied microbiology and biotechnology · 2022Article
- Advanced mycotoxin control and decontamination techniques in view of an increased aflatoxin risk in Europe due to climate change.Frontiers in microbiology · 2022Review
- May phytophenolics alleviate aflatoxins-induced health challenges? A holistic insight on current landscape and future prospects.Frontiers in nutrition · 2022Review
- The Solvent Dimethyl Sulfoxide Affects Physiology, Transcriptome and Secondary Metabolism ofJournal of fungi (Basel, Switzerland) · 2021Article
- Current Approaches for Advancement in Understanding the Molecular Mechanisms of Mycotoxin Biosynthesis.International journal of molecular sciences · 2021Review
- Functional Biology and Molecular Mechanisms of Host-Pathogen Interactions for Aflatoxin Contamination in Groundnut (Frontiers in microbiology · 2020Review
- Article
- Article
- Review
- Article
- Review
- Stilbenoid prenyltransferases define key steps in the diversification of peanut phytoalexins.The Journal of biological chemistry · 2018Article
- Aspergillus flavus infection triggered immune responses and host-pathogen cross-talks in groundnut during in-vitro seed colonization.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResveratrol has been reported as a natural phytoalexin that inhibits infection or the growth of certain fungi including Aspergillus flavus. Our previous research revealed that aflatoxin production in A. flavus was reduced in medium with resveratrol. To understand the molecular mechanism of the A. flavus response to resveratrol treatment, the high-throughput paired-end RNA-Seq was applied to analyze the transcriptomic profiles of A. flavus.
resultsIn total, 366 and 87 genes of A. flavus were significantly up- and down- regulated, respectively, when the fungus was treated with resveratrol. Gene Ontology (GO) functional enrichment analysis revealed that 48 significantly differentially expressed genes were involved in 6 different terms. Most genes in the aflatoxin biosynthetic pathway genes cluster (#54) did not show a significant change when A. flavus was treated with resveratrol, but 23 of the 30 genes in the #54 cluster were down-regulated. The transcription of aflA and aflB was significantly suppressed under resveratrol treatment, resulting in an insufficient amount of the starter unit hexanoate for aflatoxin biosynthesis. In addition, resveratrol significantly increased the activity of antioxidative enzymes that destroy radicals, leading to decreased aflatoxin production. Moreover, stuA, fluG, flbC, and others genes involved in mycelial and conidial development were down-regulated, which disrupted the cell's orderly differentiation and blocked conidia formation and mycelia development. The transcripts of laeA and veA were slightly inhibited by resveratrol, which may partly decrease aflatoxin production and depress conidia formation.
conclusionsResveratrol can affect the expression of A. flavus genes that are related to developmental and secondary metabolic processes, resulting in decreased aflatoxin production and conidia formation and could also cause abnormal mycelia development. These results provide insight into the transcriptome of A. flavus in response to resveratrol and a new clew for further study in regulation of aflatoxin biosynthesis in A. flavus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.