Evidence map›Paper›PMID 26420041›Full record

ArticleJournal of materials science. Materials in medicine2015

3D fibre deposition and stereolithography techniques for the design of multifunctional nanocomposite magnetic scaffolds.

Roberto De Santis, Ugo D'Amora, Teresa Russo, Alfredo Ronca, Antonio Gloria, Luigi Ambrosio

Abstract read
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In one paragraph

Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation.Journal of biomedical materials research. Part B, Applied biomaterials · 2026
    Review
  2. Article
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  6. Review
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  8. Article
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  11. Additive manufacturing of bone scaffolds.International journal of bioprinting · 2019
    Review
  12. Review
  13. 3D and 4D Printing of Polymers for Tissue Engineering Applications.Frontiers in bioengineering and biotechnology · 2019
    Review
  14. 3D fiber deposited polymeric scaffolds for external auditory canal wall.Journal of materials science. Materials in medicine · 2018
    Article
  15. Article
  16. From intricate to integrated: Biofabrication of articulating joints.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017
    Review
  17. Article
  18. Article
  19. Article
  20. Effect of topical antiinflammatory drugs on mechanical behavior of rabbit cornea.Journal of applied biomaterials & functional materials · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Roberto De SantisInstitute of Polymers, Composites and Biomaterials, National Research Council of Italy, V. le J.F. Kennedy 54 - Pad. 20 Mostra d'Oltremare, 80125, Naples, Italy. rosantis@unina.it.
Ugo D'AmoraInstitute of Polymers, Composites and Biomaterials, National Research Council of Italy, V. le J.F. Kennedy 54 - Pad. 20 Mostra d'Oltremare, 80125, Naples, Italy.
Teresa RussoInstitute of Polymers, Composites and Biomaterials, National Research Council of Italy, V. le J.F. Kennedy 54 - Pad. 20 Mostra d'Oltremare, 80125, Naples, Italy.
Alfredo RoncaInstitute of Polymers, Composites and Biomaterials, National Research Council of Italy, V. le J.F. Kennedy 54 - Pad. 20 Mostra d'Oltremare, 80125, Naples, Italy.
Antonio GloriaInstitute of Polymers, Composites and Biomaterials, National Research Council of Italy, V. le J.F. Kennedy 54 - Pad. 20 Mostra d'Oltremare, 80125, Naples, Italy.
Luigi AmbrosioDepartment of Chemical Science and Materials Technology, National Research Council of Italy, Piazzale Aldo Moro 7, 00185, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic nanocomposite scaffolds based on poly(ε-caprolactone) and poly(ethylene glycol) were fabricated by 3D fibre deposition modelling (FDM) and stereolithography techniques. In addition, hybrid coaxial and bilayer magnetic scaffolds were produced by combining such techniques. The aim of the current research was to analyse some structural and functional features of 3D magnetic scaffolds obtained by the 3D fibre deposition technique and by stereolithography as well as features of multimaterial scaffolds in the form of coaxial and bilayer structures obtained by the proper integration of such methods. The compressive mechanical behaviour of these scaffolds was investigated in a wet environment at 37 °C, and the morphological features were analysed through scanning electron microscopy (SEM) and X-ray micro-computed tomography. The capability of a magnetic scaffold to absorb magnetic nanoparticles (MNPs) in water solution was also assessed. confocal laser scanning microscopy was used to assess the in vitro biological behaviour of human mesenchymal stem cells (hMSCs) seeded on 3D structures. Results showed that a wide range of mechanical properties, covering those spanning hard and soft tissues, can be obtained by 3D FDM and stereolithography techniques. 3D virtual reconstruction and SEM showed the precision with which the scaffolds were fabricated, and a good-quality interface between poly(ε-caprolactone) and poly(ethylene glycol) based scaffolds was observed for bilayer and coaxial scaffolds. Magnetised scaffolds are capable of absorbing water solution of MNPs, and a preliminary information on cell adhesion and spreading of hMSCs was obtained without the application of an external magnetic field.

Indexed as

Biomechanical PhenomenaCells, CulturedCompressive StrengthHumansImaging, Three-DimensionalMagnetite NanoparticlesMaterials TestingMesenchymal Stem CellsMicroscopy, Electron, ScanningNanocompositesPolyestersPrinting, Three-DimensionalTissue EngineeringTissue ScaffoldsX-Ray MicrotomographyMagnetite NanoparticlespolycaprolactonePolyesters

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.