ArticleScientific reports2015
Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 73 citations in OpenAlex.
- Flavonoids as Dual Topoisomerase I and II Inhibitors: Mechanistic Insights and Emerging Anticancer Strategies.Chemistry & biodiversity · 2026Review
- Antioxidant Potential, Genotoxic Safety, and Metabolomic Profiling of Cladode Extracts fromAntioxidants (Basel, Switzerland) · 2026Article
- Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion.Cell reports · 2025Article
- Quercetin-Loaded Ginkgo Starch Nanoparticles: A Promising Strategy to Improve Bioactive Delivery and Cellular Homeostasis in Functional Foods.Foods (Basel, Switzerland) · 2025Article
- Phytomolecules from Herbs: Possible Effective Way for the Treatment of Liver Cancer.Current topics in medicinal chemistry · 2025Review
- Safety and efficacy of a feed additive consisting of aEFSA journal. European Food Safety Authority · 2024Article
- Safety and efficacy of a feed additive consisting of a dry extract obtained from the leaves ofEFSA journal. European Food Safety Authority · 2024Article
- Nano-Ayurvedic Medicine Approaches UsingNanotechnology, science and applications · 2024Article
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- In Vitro Anti-Diabetic, Anti-Inflammatory, Antioxidant Activities and Toxicological Study of OptimizedPharmaceuticals (Basel, Switzerland) · 2023Article
- Article
- Effects of Flavonoids on Cancer, Cardiovascular and Neurodegenerative Diseases: Role of NF-κB Signaling Pathway.International journal of molecular sciences · 2023Review
- Radical Scavenging Potential of Ginkgolides and Bilobalide: Insight from Molecular Modeling.Antioxidants (Basel, Switzerland) · 2023Article
- Article
- Top2a promotes the development of social behavior via PRC2 and H3K27me3.Science advances · 2022Article
- Chromatographic Profile and Redox-Modulating Capacity of Methanol Extract from Seeds ofLife (Basel, Switzerland) · 2022Article
- Associations between intake of dietary flavonoids and the 10-year incidence of tinnitus in older adults.European journal of nutrition · 2022Article
- Review
- Potential Multifunctional Bioactive Compounds fromJournal of inflammation research · 2022Article
- Improving the Health-Benefits of Kales (Plants (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ginkgo biloba leaf extract has been shown to increase the incidence in liver tumors in mice in a 2-year bioassay conducted by the National Toxicology Program. In this study, the DNA damaging effects of Ginkgo biloba leaf extract and many of its constituents were evaluated in human hepatic HepG2 cells and the underlying mechanism was determined. A molecular docking study revealed that quercetin, a flavonoid constituent of Ginkgo biloba, showed a higher potential to interact with topoisomerase II (Topo II) than did the other Ginkgo biloba constituents; this in silico prediction was confirmed by using a biochemical assay to study Topo II enzyme inhibition. Moreover, as measured by the Comet assay and the induction of γ-H2A.X, quercetin, followed by keampferol and isorhamnetin, appeared to be the most potent DNA damage inducer in HepG2 cells. In Topo II knockdown cells, DNA damage triggered by Ginkgo biloba leaf extract or quercetin was dramatically decreased, indicating that DNA damage is directly associated with Topo II. DNA damage was also observed when cells were treated with commercially available Ginkgo biloba extract product. Our findings suggest that Ginkgo biloba leaf extract- and quercetin-induced in vitro genotoxicity may be the result of Topo II inhibition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.