ArticleJournal of experimental & clinical cancer research : CR2015
miR-96 suppresses renal cell carcinoma invasion via downregulation of Ezrin expression.
Article in Journal of experimental & clinical cancer research : CR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- miR-96-5p targets PTEN to mediate sunitinib resistance in clear cell renal cell carcinoma.Scientific reports · 2022Article
- MicroRNA-96: A therapeutic and diagnostic tumor marker.Iranian journal of basic medical sciences · 2022Review
- MicroRNAs: The Link between the Metabolic Syndrome and Oncogenesis.International journal of molecular sciences · 2021Review
- miR-96-5p regulated TGF-β/SMAD signaling pathway and suppressed endometrial cell viability and migration via targeting TGFBR1.Cell cycle (Georgetown, Tex.) · 2020Article
- Ezrin Mediates Invasion and Metastasis in Tumorigenesis: A Review.Frontiers in cell and developmental biology · 2020Review
- Prognostic role of GPER/Ezrin in triple-negative breast cancer is associated with menopausal status.Endocrine connections · 2019Article
- The miR-183/182/96 cluster functions as a potential carcinogenic factor and prognostic factor in kidney renal clear cell carcinoma.Experimental and therapeutic medicine · 2019Article
- Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells.Cell communication and signaling : CCS · 2018Article
- Genome-wide Profiling of Urinary Extracellular Vesicle microRNAs Associated With Diabetic Nephropathy in Type 1 Diabetes.Kidney international reports · 2018Article
- ZO-1 expression is suppressed by GM-CSF via miR-96/ERG in brain microvascular endothelial cells.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Anticancer effect of miR-96 inhibitor in bladder cancer cell lines.Oncology letters · 2018Article
- Construction of a specific SVM classifier and identification of molecular markers for lung adenocarcinoma based on lncRNA-miRNA-mRNA network.OncoTargets and therapy · 2018Article
- Resveratrol ameliorates hypoxia/ischemia-induced brain injury in the neonatal rat via the miR-96/Bax axis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Overexpression of miR-96 promotes cell proliferation by targeting FOXF2 in prostate cancer.International journal of clinical and experimental pathology · 2017Article
- Local microRNA delivery targets Palladin and prevents metastatic breast cancer.Nature communications · 2016Article
- Predicting MicroRNA Biomarkers for Cancer Using Phylogenetic Tree and Microarray Analysis.International journal of molecular sciences · 2016Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study examined the role of microRNA (miR)-96 in renal cell carcinoma (RCC) invasion.
methodsThe expression of miR-96 was detected by quantitative reverse transcription-polymerase chain reaction in human RCC cell lines with high (Caki-1) and low (786-O) metastatic potential. Invasive ability and Ezrin expression were assessed in Caki-1 and 786-O cells transfected with a miR-96 mimic or inhibitor using wound healing assays, Transwell assays and western blotting. Expression of miR-96 and Ezrin was also examined in primary RCC samples from 17 patients with metastatic disease and 46 patients who maintained remission during a follow-up period of 37 months.
resultsmiR-96 expression was significantly lower in Caki-1compared to786-O cells. The invasive ability of Caki-1 and 786-O cells increased following transfection of cells with miR-96 inhibitor, whereas it decreased following transfection with miR-96 mimic. Ezrin levels were negatively correlated with miR-96 in RCC, and inhibition of Ezrin expression suppressed the miR-96-induced change in invasive ability. The negative correlation between miR-96 and metastasis/Ezrin expression was also observed in human RCC specimens.
conclusionsThese results suggest that miR-96 suppresses RCC invasion by modulating Ezrin expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.