ArticleJournal of neuro-oncology2016
Illness intrusiveness and subjective well-being in patients with glioblastoma.
Article in Journal of neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Depression and glioblastoma, complicated concomitant diseases: a systemic review of published literature.Neurosurgical review · 2020Pooled it
- Survival outcomes associated with antidepressant use in glioblastoma: a cohort study.Journal of neuro-oncology · 2025Article
- Psycho-oncological burden in patients with brain metastases undergoing neurological surgery.Frontiers in oncology · 2024Article
- Illness Intrusiveness in Adults with Sickle Cell Disease: The Role of Fatigue.Journal of clinical psychology in medical settings · 2023Article
- Neurocognitive impairment, neurobehavioral symptoms, fatigue, sleep disturbance, and depressive symptoms in patients with newly diagnosed glioblastoma.Neuro-oncology practice · 2023Article
- Study on anxiety, depression, and subjective wellbeing of patients with bladder cancer in their different chemotherapy stages.Frontiers in psychology · 2023Article
- Effect of family resilience on subjective well-being in patients with advanced cancer: the chain mediating role of perceived social support and psychological resilience.Frontiers in psychology · 2023Article
- Article
- Characteristics of health-related quality of life and related factors in patients with brain tumors treated with rehabilitation therapy.Journal of patient-reported outcomes · 2022Article
- Quality of life in patients with glioblastoma and their relatives.Acta neurologica Scandinavica · 2022Article
- Article
- Causes of Death and End-of-Life Care in Patients With Intracranial High-Grade Gliomas: A Retrospective Observational Study.Neurology · 2022Observational
- Understanding subjective well-being: perspectives from psychology and public health.Public health reviews · 2020Review
- Palliative Care in High-Grade Glioma: A Review.Brain sciences · 2020Review
- Health-related quality of life and emotional well-being in patients with glioblastoma and their relatives.Journal of neuro-oncology · 2020Article
- The interplay among psychological distress, the immune system, and brain tumor patient outcomes.Current opinion in behavioral sciences · 2019Article
- Association between depression and brain tumor: a systematic review and meta-analysis.Oncotarget · 2017Article
- Psychosocial distress and its effects on the health-related quality of life of primary brain tumor patients.CNS oncology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioblastoma (GBM) is the most common adult CNS malignancy but its impact on quality of life (QOL) is poorly understood. In other patient populations, illness intrusiveness (the extent to which disease and treatment disrupts valued activities and interests) is associated with low subjective well-being, after controlling for disease and treatment variables. In this cross-sectional cohort study, we examined the relations among illness intrusiveness, disease burden, and subjective well-being in GBM. 73 GBM patients completed validated self-report measures of depression, positive affect, illness intrusiveness, and health-related QOL. Responses were compared to data from six other cancer groups using repeated measures analyses of variance. Hierarchical multiple-regression analyses tested the hypothesis that illness intrusiveness accounts for well-being after controlling for the effects of disease burden. GBM patients reported less positive affect, more depression, and more illness intrusiveness than people with other cancers. Illness intrusiveness correlated with depression and (low) positive affect. Associations among cancer symptoms, depression, and positive affect decreased when illness intrusiveness was added to regression equations. Good performance status and high cancer-symptom burden were associated with illness intrusiveness and depression. GBM patients report greater distress, lower positive affect, and more illness intrusiveness than people with other cancers. Subjective well-being is mediated in part by illness intrusiveness in this population. In addition to medical treatment, efforts to help patients remain engaged in valued activities and interests may help preserve QOL after the diagnosis of a GBM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.