Evidence map›Paper›PMID 26419755›Full record

ReviewJournal of the American Society of Hypertension : JASH2015

Vitamin D deficiency and essential hypertension.

Songcang Chen, Yingxian Sun, Devendra K Agrawal

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American Society of Hypertension : JASH, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Vitamin D and Brain Health.Advances in experimental medicine and biology · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Vitamin D and hypertension: Is there any significant relation?Chronic diseases and translational medicine · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Songcang ChenCenter for Clinical & Translational Science and Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, USA. Electronic address: SongcangChen@creighton.edu.
Yingxian SunDepartment of Cardiology, First Affiliated Hospital, China Medical University, Shenyang, People's Republic of China.
Devendra K AgrawalCenter for Clinical & Translational Science and Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, USA.
Creighton University · USChina Medical University · CN

Funding

EPICARDIAL ADIPOSE TISSUE, OBESITY AND INFLAMMATION IN ATHEROSCLEROSISR01HL120659 · NHLBI · CREIGHTON UNIVERSITY · PI AGRAWAL, DEVENDRA K. · 2013 to 2017
$3.6M
VITAMIN D AND IMMUNOMODULATION IN CORONARY ARTERY DISEASER01HL116042 · NHLBI · CREIGHTON UNIVERSITY · PI AGRAWAL, DEVENDRA K. · 2012 to 2016
$3.3M
A Role for Non-Hypercalcemic VDR Agonists in the Control of VSMC ProliferationR21HL096047 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHEN, SONGCANG · 2010 to 2011
$425k
NHLBI NIH HHS HL096047NHLBI NIH HHS R01 HL116042NHLBI NIH HHS R01 HL120659NHLBI NIH HHS R21 HL096047
6 · The paper itself

Abstract

Essential hypertension (EH) results when the balance between vasoconstriction and vasodilation is shifted in favor of vasoconstriction. This balance is controlled by the interaction of genetic and epigenetic factors. When there is an unstable balance, vitamin D deficiency as an epigenetic factor triggers a shift to the side of vasoconstriction. In this article, we critically analyze clinical findings on the effect of vitamin D on blood pressure, combined with progress in molecular mechanisms. We find that vitamin D repletion exerts a clinically significant antihypertensive effect in vitamin D-deficient EH patients. Of note, a few trials reported no antihypertensive effect from vitamin D due to suboptimal study design. Short-term vitamin D supplementation has no effect on blood pressure in normotensive subjects. This could explain the mixed results and may provide a theoretical basis for future trials to identify beneficial effects of vitamin D in intervention for EH.

Indexed as

Antihypertensive AgentsComorbidityCross-Sectional StudiesEssential HypertensionFemaleFollow-Up StudiesHumansHypertensionMalePrevalenceProspective StudiesRandomized Controlled Trials as TopicRisk AssessmentSeverity of Illness IndexTreatment OutcomeVitamin DAntihypertensive AgentsVitamin Dclinical trialEssential hypertensionmolecular mechanismvitamin D

Identifiers

PMID26419755
PMCPMC4641765
OpenAlexW2102390615

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.