ReviewGenes, brain, and behavior2016
Developmental regulation of fear learning and anxiety behavior by endocannabinoids.
Review in Genes, brain, and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 67 citations in OpenAlex.
- Ontogeny of Rat Recognition Memory, Exploratory Activity and Anxiety Measured by Novel Object Recognition Test and Open Field Test.Annals of neurosciences · 2026Article
- Age-Related Effects of Cannabis and Cannabinoids on Brain and Behavior.Cannabis and cannabinoid research · 2026Review
- The role of the kynurenine pathway in conditioned place aversion induced by synthetic cannabinoid CP-55940.Behavioral and brain functions : BBF · 2026Article
- Research Review: What we have learned about the endocannabinoid system in developmental psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Fatty acid amide hydrolase in major depressive episodes: A [Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Impaired mnemonic pattern separation associated with PTSD symptoms paradoxically improves with regular cannabis use.Npj mental health research · 2025Article
- Effects of pharmacological inhibition of fatty acid amide hydrolase on corticosterone release: a systematic review of preclinical studies.Discover mental health · 2025Review
- Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats.Psychopharmacology · 2025Article
- Review
- Proteomic Profile of Circulating Extracellular Vesicles in the Brain after Δ9-Tetrahydrocannabinol Inhalation.Biomolecules · 2024Article
- Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats.bioRxiv : the preprint server for biology · 2024Article
- Acute cannabidiol treatment enhances social interaction in adult male mice.Advances in drug and alcohol research · 2023Article
- Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Genetic variation in endocannabinoid signaling is associated with differential network-level functional connectivity in youth.Journal of neuroscience research · 2022Article
- Maturation of amygdala inputs regulate shifts in social and fear behaviors: A substrate for developmental effects of stress.Neuroscience and biobehavioral reviews · 2021Review
- Review
- Fear extinction learning and anandamide: an fMRI study in healthy humans.Translational psychiatry · 2021Article
- Do Adolescent Exposure to Cannabinoids and Early Adverse Experience Interact to Increase the Risk of Psychiatric Disorders: Evidence from Rodent Models.International journal of molecular sciences · 2021Review
- Targeting the Endocannabinoid System in Borderline Personality Disorder: Corticolimbic and Hypothalamic Perspectives.Current neuropharmacology · 2021Review
- Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders.Biomolecules · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The developing brain undergoes substantial maturation into adulthood and the development of specific neural structures occurs on differing timelines. Transient imbalances between developmental trajectories of corticolimbic structures, which are known to contribute to regulation over fear learning and anxiety, can leave an individual susceptible to mental illness, particularly anxiety disorders. There is a substantial body of literature indicating that the endocannabinoid (eCB) system critically regulates stress responsivity and emotional behavior throughout the life span, making this system a novel therapeutic target for stress- and anxiety-related disorders. During early life and adolescence, corticolimbic eCB signaling changes dynamically and coincides with different sensitive periods of fear learning, suggesting that eCB signaling underlies age-specific fear learning responses. Moreover, perturbations to these normative fluctuations in corticolimbic eCB signaling, such as stress or cannabinoid exposure, could serve as a neural substrate contributing to alterations to the normative developmental trajectory of neural structures governing emotional behavior and fear learning. In this review, we first introduce the components of the eCB system and discuss clinical and rodent models showing eCB regulation of fear learning and anxiety in adulthood. Next, we highlight distinct fear learning and regulation profiles throughout development and discuss the ontogeny of the eCB system in the central nervous system, and models of pharmacological augmentation of eCB signaling during development in the context of fear learning and anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.