ArticleEuropean journal of nutrition2016
Betaine is as effective as folate at re-synthesizing methionine for protein synthesis during moderate methionine deficiency in piglets.
Article in European journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Intrauterine Growth-Restricted Female Yucatan Miniature Pig Neonates Fed Parenteral Nutrition Exhibit Early Catch-Up Growth Leading to Obesity and Ectopic Fat Deposition in Adulthood.The Journal of nutrition · 2025Article
- Postprandial Plasma and Whole Blood Amino Acids Are Largely Indicative of Dietary Amino Acids in Adult Dogs Consuming Diets with Increasing Whole Pulse Ingredient Inclusion.The Journal of nutrition · 2024Article
- Neuroprotective Roles of the Reverse Transsulfuration Pathway in Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- Metabonomic Responses of Grazing Yak to Different Concentrate Supplementations in Cold Season.Animals : an open access journal from MDPI · 2020Article
- Metabolite and gene expression profiles suggest a putative mechanism through which high dietary carbohydrates reduce the content of hepatic betaine in Megalobrama amblycephala.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Betaine reduces β-amyloid-induced paralysis through activation of cystathionine-β-synthase in an Alzheimer model ofGenes & nutrition · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBoth folate and betaine (synthesized from choline) are nutrients used to methylate homocysteine to reform the amino acid methionine following donation of its methyl group; however, it is unclear whether both remethylation pathways are of equal importance during the neonatal period when remethylation rates are high. Methionine is an indispensable amino acid that is in high demand in neonates not only for protein synthesis, but is also particularly important for transmethylation reactions, such as creatine and phosphatidylcholine synthesis. The objective of this study was to determine whether supplementation with folate, betaine, or a combination of both can equally re-synthesize methionine for protein synthesis when dietary methionine is limiting.
methodsPiglets were fed a low methionine diet devoid of folate, choline, and betaine, and on day 6, piglets were supplemented with either folate, betaine, or folate + betaine (n = 6 per treatment) until day 10. [1-
resultsPrior to supplementation, piglets had lower concentrations of plasma folate, betaine, and choline compared to baseline with no change in homocysteine. Post-supplementation, phenylalanine oxidation levels were 20-46 % lower with any methyl donor supplementation (P = 0.006) with no difference among different supplementation groups. Furthermore, both methyl donors led to similarly lower concentrations of homocysteine following supplementation (P < 0.05).
conclusionsThese data demonstrate an equal capacity for betaine and folate to remethylate methionine for protein synthesis, as indicated by lower phenylalanine oxidation.
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