Evidence map›Paper›PMID 26419583›Full record

Trial reportEuropean journal of nutrition2017

Daily intake of fermented milk with Lactobacillus casei strain Shirota reduces the incidence and duration of upper respiratory tract infections in healthy middle-aged office workers.

Kan Shida, Tadashi Sato, Ryoko Iizuka, Ryotaro Hoshi, Osamu Watanabe, Tomoki Igarashi, Kouji Miyazaki, Masanobu Nanno, Fumiyasu Ishikawa

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 12 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 12 syntheses or guidelines pooled it, 143 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Frontiers in immunology · 2025
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Probiotics for preventing acute upper respiratory tract infections.The Cochrane database of systematic reviews · 2022
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Effects of Heat-TreatedNutrients · 2024
    Trial
  14. Frontiers in immunology · 2024
    Trial
  15. Effects ofNutrients · 2023
    Trial
  16. Effect of Oral Administration ofInternational journal of environmental research and public health · 2022
    Trial
  17. Trial
  18. Trial
  19. Trial
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kan ShidaYakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo, 186-8650, Japan. kan-shida@yakult.co.jp.
Tadashi SatoYakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo, 186-8650, Japan.
Ryoko IizukaYakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo, 186-8650, Japan.
Ryotaro HoshiFaculty of Research and Development, Yakult Honsha, Shinbashi, Tokyo, 105-8660, Japan.
Osamu WatanabeFaculty of Research and Development, Yakult Honsha, Shinbashi, Tokyo, 105-8660, Japan.
Tomoki IgarashiFaculty of Research and Development, Yakult Honsha, Shinbashi, Tokyo, 105-8660, Japan.
Kouji MiyazakiYakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo, 186-8650, Japan.
Masanobu NannoYakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo, 186-8650, Japan.
Fumiyasu IshikawaYakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo, 186-8650, Japan.
Yakult Central Institute · JPYakult Honsha (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlthough several studies have demonstrated the efficacy of probiotics for preventing upper respiratory tract infections (URTIs) in at-risk populations, including children and the elderly, few studies have investigated the efficacy of probiotics in healthy adults living normal, everyday lives. Thus, we tried to evaluate the effects of Lactobacillus casei strain Shirota-fermented milk (LcS-FM) on the incidence of URTIs in healthy middle-aged office workers.

methodsIn a randomized controlled trial, 96 eligible male workers aged 30-49 years consumed LcS-FM containing 1.0 × 10

resultsThe incidence of URTIs during the intervention period was significantly lower in the LcS-FM group than in the CM group (22.4 vs. 53.2 %, P = 0.002). The time-to-event analysis showed that the LcS-FM group had a significantly higher URTI-free rate than the CM group over the test period (log-rank test: χ

conclusionThe results suggest that the daily intake of fermented milk with LcS may reduce the risk of URTIs in healthy middle-aged office workers, probably through modulation of the immune system.

Indexed as

Cultured Milk ProductsLacticaseibacillus caseiAdultBody Mass IndexFermentationHumansHydrocortisoneIncidenceKiller Cells, NaturalLeukocytes, MononuclearMaleMiddle AgedProbioticsRespiratory Tract InfectionsSalivaSample SizeHydrocortisoneCommon coldCortisolLactobacillus casei strain ShirotaNK cell activityProbioticsUpper respiratory tract infection

Identifiers

PMID26419583
PMCPMC5290054
OpenAlexW2178038387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.