ReviewCurrent osteoporosis reports2015
A Mechanism-Based Approach to the Management of Osteoarthritis Pain.
Review in Current osteoporosis reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Rehabilitation Applications Based on Behavioral Therapy for People With Knee Osteoarthritis: Systematic Review.JMIR mHealth and uHealth · 2024Pooled it
- The Efficacy of Nerve Growth Factor Antibody for the Treatment of Osteoarthritis Pain and Chronic Low-Back Pain: A Meta-Analysis.Frontiers in pharmacology · 2020Pooled it
- Inferring distinct mechanisms in the absence of subjective differences: Placebo and centrally acting analgesic underlie unique brain adaptations.Human brain mapping · 2018Trial
- Neuropeptide Y signaling in osteoarthritis pain: neuroimmune mechanisms, joint remodeling, and translational opportunities.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- "Pain Prehabilitation" in Major Joint Surgery: The Way Forward to Improve Outcomes and Prevent Pain Chronicity.Journal of clinical medicine · 2025Review
- Advances in Electroacupuncture for Treatment of Knee Osteoarthritis: Mechanisms, Efficacy, and Future Directions.Journal of pain research · 2025Review
- Effect of Traditional Chinese Non-Pharmacological Therapies on Knee Osteoarthritis: A Narrative Review of Clinical Application and Mechanism.Orthopedic research and reviews · 2024Review
- Microarray analysis of signalling interactions between inflammation and angiogenesis in subchondral bone in temporomandibular joint osteoarthritis.Biomaterials translational · 2024Article
- Association of Sleep Disturbance With Catastrophizing and Knee Pain: Data From the Osteoarthritis Initiative.Arthritis care & research · 2023Article
- Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort.Journal of personalized medicine · 2023Article
- Article
- The effect of interactions between BMI and sustained depressive symptoms on knee osteoarthritis over 4 years: data from the osteoarthritis initiative.BMC musculoskeletal disorders · 2023Article
- Review
- Predicting Depression in Patients With Knee Osteoarthritis Using Machine Learning: Model Development and Validation Study.JMIR formative research · 2022Article
- Article
- Altered activity of pain processing brain regions in association with hip osteoarthritis.Scientific reports · 2022Article
- Activity-related pain predicts pain and functional outcomes in people with knee osteoarthritis: A longitudinal study.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Involvement of Macrophages and Spinal Microglia in Osteoarthritis Pain.Current rheumatology reports · 2021Review
- Mesenchymal stem cells in osteoarthritis therapy: a review.American journal of translational research · 2021Review
- Identifying subgroups of community-dwelling older adults and their prospective associations with long-term knee osteoarthritis outcomes.Clinical rheumatology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Pain from osteoarthritis (OA) affects millions of people worldwide, yet treatments are limited to acetaminophen, NSAIDs, physical therapy, and ultimately, surgery when there is significant disability. In recent years, our understanding of pain pathways in OA has developed considerably. Though joint damage and inflammation play a significant role in pain generation, it is now understood that both central and peripheral nervous system mechanisms exacerbate symptoms. Evolving management strategies for OA address central factors (e.g., sleep difficulties, catastrophizing, and depression) with treatments such as cognitive behavioral therapy and exercise. In addition, emerging data suggest that antibodies against peripheral signaling neuropeptides, such as nerve growth factor-1 (NGF-1), may significantly alleviate pain. However, concerns regarding potential adverse effects, such as rapidly progressive OA, still remain. A nuanced understanding is essential if we are to make headway in developing more effective treatments for OA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.