Observational studyReproductive biology and endocrinology : RB&E2015
Dynamic alteration of serum testosterone with aging: a cross-sectional study from Shanghai, China.
Observational study in Reproductive biology and endocrinology : RB&E, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- The transcriptomic signature of age and sex is not conserved in human primary myotubes.Skeletal muscle · 2026Article
- Impact of sex and serum lipids interaction on working memory: A large-scale brain networks study.Brain and behavior · 2023Article
- Sex-dependent gut microbiota-brain-cognition associations: a multimodal MRI study.BMC neurology · 2023Article
- The number of the intraepithelial T cells correlate with the proliferation index in human bulbourethral gland epithelium.Heliyon · 2022Article
- Isorhamnetin: a flavonoid, attenuated doxorubicin-induced testicular injury via regulation of steroidogenic enzymes and apoptotic signaling gene expression in male rats.Toxicology research · 2022Article
- Beyond Binary: Influence of Sex and Gender on Outcome after Traumatic Brain Injury.Journal of neurotrauma · 2020Review
- Article
- Observational
- Comparing calculated free testosterone with total testosterone for screening and diagnosing late-onset hypogonadism in aged males: A cross-sectional study.Journal of clinical laboratory analysis · 2017Article
- Correlations Between Personality and Brain Structure: A Crucial Role of Gender.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- High Prevalence of Low Serum Biologically Active Testosterone in Older Male Veterans.Journal of the American Medical Directors Association · 2017Article
- Testosterone: Relationships with Metabolic Disorders in Men-An Observational Study from SPECT-China.International journal of endocrinology · 2017Article
- Sex as a Biological Variable: Who, What, When, Why, and How.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLevel of the testosterone in a man's life span is very important. Studies on the serum testosterone concentrations in different age groups of healthy men were controversial. The aim of this study was to investigate dynamic changes of serum reproductive hormones with aging in healthy Chinese male and to compare its correlation with age.
methodsTotal of 1,093 healthy Chinese men from Shanghai aged from 20 to 87 years old was enrolled in the study. Concentrations of serum total testosterone (T), luteinizing hormone (LH) and sex hormone binding globulin (SHBG) were quantified by EIA. Testosterone secretion index (TSI) and free testosterone index (FTI) were then calculated. Data were analyzed by SPSS program. Non-parametric tests and univariate linear regression analyses were used.
resultsThe 1,039 male participants were grouped into 12 groups by 5-year apart for each group. Significant differences in T, LH, SHBG, FTI and TSI were found between the 12 different age groups. Average of serum total T was 15.36 ± 4.86 nmol/L; LH was 4.76 ± 2.76 IU/L, SHBG was 32.61 ± 17.24 nmol/L. Compared to age 20 ~ 24 group, serum T level of age 35 ~ 39, 40 ~ 44, 45 ~ 49, 50 ~ 54, and 55 ~ 59 was significantly decreased (p < 0.05). Intriguingly, however, serum T level of age 60 or older did not significantly reduced compared to the age of 20 ~ 24 group. Serum LH and SHBG were positively correlated with aging (p <0.01), while TSI and FTI were negatively correlated with aging (p <0.01). In addition, BMI was negatively and significantly correlated with levels of T (r = -0.585, p < 0.001), LH (r = -0.090, p < 0.001), SHBG (r = - 1.817, p < 0.001), and TSI (r = - 0.104, p < 0.001), but positively and significantly correlated with FTI level (r = 0.011, p < 0.001).
conclusionSerum total testosterone fluctuated with aging in adult men, and FTI and TSI decreased gradually with aging. While age was not significantly correlated with T level, BMI was significantly and negatively correlated with T level, suggesting body weight may affect testosterone level.
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