Trial reportNature communications2015
Cognitive tutoring induces widespread neuroplasticity and remediates brain function in children with mathematical learning disabilities.
Trial report in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 5 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Examination of common and unique brain regions for atypical reading and math: a meta-analysis.Cerebral cortex (New York, N.Y. : 1991) · 2023Pooled it
- Dysfunctions associated with the intraparietal sulcus and a distributed network in individuals with math learning difficulties: An ALE meta-analysis.Human brain mapping · 2023Pooled it
- Foundational Number Sense Training Gains Are Predicted by Hippocampal-Parietal Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Pooled it
- Training-Induced Neural Plasticity in Youth: A Systematic Review of Structural and Functional MRI Studies.Frontiers in human neuroscience · 2020Pooled it
- Brain areas associated with numbers and calculations in children: Meta-analyses of fMRI studies.Developmental cognitive neuroscience · 2018Pooled it
- Symbolic and non-symbolic geometric abilities across development and in individuals with dyscalculia and dyslexia.iScience · 2026Article
- Review
- Latent Neurocognitive Mechanisms Underlying Quantity Discrimination in Children with and without Mathematical Learning Disabilities.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Answer-locked ERP dynamics during arithmetic verification in children with developmental dyscalculia.Frontiers in psychiatry · 2026Article
- Visualizations during arithmetic tasks hamper performance and increase cognitive load in 9-year-olds: an fNIRS study.Frontiers in psychology · 2026Article
- Familial transmission of neural representations for mental arithmetic across two generations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Distinct neural representational changes following cross-format number tutoring in children with mathematical difficulties.NPJ science of learning · 2025Article
- Personalized deep neural networks reveal mechanisms of math learning disabilities in children.Science advances · 2025Article
- Looking at Philosophy for Children and Its Outcomes Through a Neuroscience Lens.Basic and clinical neuroscience · 2025Review
- Development of the arcuate fasciculus is linked to learning gains in reading.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Charting the knowledge landscape of mathematics learning disabilities: an analysis of intellectual structure and research frontiers.Frontiers in psychology · 2025Review
- Short-term number sense training recapitulates long-term neurodevelopmental changes from childhood to adolescence.Developmental science · 2024Article
- Long-term abacus training gains in children are predicted by medial temporal lobe anatomy and circuitry.Developmental science · 2024Article
- Differences in educational opportunity predict white matter development.Developmental cognitive neuroscience · 2024Article
- Neuroanatomical, transcriptomic, and molecular correlates of math ability and their prognostic value for predicting learning outcomes.Science advances · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Competency with numbers is essential in today's society; yet, up to 20% of children exhibit moderate to severe mathematical learning disabilities (MLD). Behavioural intervention can be effective, but the neurobiological mechanisms underlying successful intervention are unknown. Here we demonstrate that eight weeks of 1:1 cognitive tutoring not only remediates poor performance in children with MLD, but also induces widespread changes in brain activity. Neuroplasticity manifests as normalization of aberrant functional responses in a distributed network of parietal, prefrontal and ventral temporal-occipital areas that support successful numerical problem solving, and is correlated with performance gains. Remarkably, machine learning algorithms show that brain activity patterns in children with MLD are significantly discriminable from neurotypical peers before, but not after, tutoring, suggesting that behavioural gains are not due to compensatory mechanisms. Our study identifies functional brain mechanisms underlying effective intervention in children with MLD and provides novel metrics for assessing response to intervention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.