Evidence map›Paper›PMID 26419399›Full record

ArticleVeterinary pathology2016

Systemic Amyloid A Amyloidosis in Island Foxes (Urocyon littoralis): Severity and Risk Factors.

P M Gaffney, C Witte, D L Clifford, D M Imai, T D O'Brien, M Trejo, F Liberta, K Annamalai, M Fändrich, E Masliah and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

P M GaffneyDepartments of Pathology and Medicine, University of California-San Diego, La Jolla, CA, USA Department of Pathology, Immunology, and Microbiology, University of California-Davis, Davis, CA, USA.
C WitteWildlife Disease Laboratories, Institute for Conservation Research, San Diego Zoo Global, Escondido, CA, USA.
D L CliffordWildlife Investigations Laboratory, California Department of Fish and Wildlife, Rancho Cordova, CA, USA Department of Veterinary Medicine and Epidemiology, University of California-Davis, Davis, CA, USA.
D M ImaiDepartment of Pathology, Immunology, and Microbiology, University of California-Davis, Davis, CA, USA.
T D O'BrienVeterinary Population Medicine Department, Veterinary Diagnostic Laboratory, University of Minnesota, St Paul, MN, USA.
M TrejoDepartments of Pathology and Neuroscience, University of California-San Diego, La Jolla, CA, USA.
F LibertaInstitute for Pharmaceutical Biotechnology, Ulm University, Helmholtzstrasse, Ulm, Germany.
K AnnamalaiInstitute for Pharmaceutical Biotechnology, Ulm University, Helmholtzstrasse, Ulm, Germany.
M FändrichInstitute for Pharmaceutical Biotechnology, Ulm University, Helmholtzstrasse, Ulm, Germany.
E MasliahDepartments of Pathology and Neuroscience, University of California-San Diego, La Jolla, CA, USA.
L MunsonDepartment of Pathology, Immunology, and Microbiology, University of California-Davis, Davis, CA, USA Deceased Supplemental material for this article is available on the Veterinary Pathology website at http://vet.sagepub.com/supplemental.
C J SigurdsonDepartments of Pathology and Medicine, University of California-San Diego, La Jolla, CA, USA Department of Pathology, Immunology, and Microbiology, University of California-Davis, Davis, CA, USA csigurdson@ucsd.edu.
Helmholtz-Institute Ulm · DEUniversity of California, Davis · USUniversity of California, San Diego · USCalifornia Department of Fish and Wildlife · USSan Diego Zoo Institute for Conservation Research · USUniversity of Minnesota · US

Funding

UCSD Research Training Program for VeterinariansT32OD017863 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ERNST, PETER B., SIGURDSON, CHRISTINA · 2014 to 2023
$2.0M
NIH HHS T32 OD017863
6 · The paper itself

Abstract

Systemic amyloid A (AA) amyloidosis is highly prevalent (34%) in endangered island foxes (Urocyon littoralis) and poses a risk to species recovery. Although elevated serum AA (SAA) from prolonged or recurrent inflammation predisposes to AA amyloidosis, additional risk factors are poorly understood. Here we define the severity of glomerular and medullary renal amyloid and identify risk factors for AA amyloidosis in 321 island foxes necropsied from 1987 through 2010. In affected kidneys, amyloid more commonly accumulated in the medullary interstitium than in the glomeruli (98% [n= 78 of 80] vs 56% [n= 45], respectively;P< .0001), and medullary deposition was more commonly severe (19% [n= 20 of 105]) as compared with glomeruli (7% [n= 7];P= .01). Univariate odds ratios (ORs) of severe renal AA amyloidosis were greater for short- and long-term captive foxes as compared with free-ranging foxes (ORs = 3.2, 3.7, respectively; overall P= .05) and for females as compared with males (OR = 2.9;P= .05). Multivariable logistic regression revealed that independent risk factors for amyloid development were increasing age class (OR = 3.8;P< .0001), San Clemente Island subspecies versus San Nicolas Island subspecies (OR = 5.3;P= .0003), captivity (OR = 5.1;P= .0001), and nephritis (OR = 2.3;P= .01). The increased risk associated with the San Clemente subspecies or captivity suggests roles for genetic as well as exogenous risk factors in the development of AA amyloidosis.

Indexed as

FoxesAmyloidosisAnimalsEndangered SpeciesFemaleInflammationKidneyLogistic ModelsMaleNephritisRisk FactorsSerum Amyloid A ProteinSeverity of Illness IndexSerum Amyloid A Proteinamyloid Aamyloidosisendangered speciesisland foxlogistic regressionnephritisserum amyloid AUrocyon littoralis

Identifiers

PMID26419399
PMCPMC4871602
OpenAlexW2195914803

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.