ArticleScientific reports2015
Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Circadian Rhythms in Gastroenterology: The Biological Clock's Impact on Gut Health.Gastroenterology · 2025Review
- Sex-specific leukocyte responses to peanut allergen: uncovering potential links to the molecular circadian clock.Journal of leukocyte biology · 2025Article
- Disruption of the intestinal clock drives dysbiosis and impaired barrier function in colorectal cancer.Science advances · 2024Article
- Effect of circadian clock and claudin regulations on inulin-induced calcium absorption in the mouse intestinal tract.Bioscience of microbiota, food and health · 2023Article
- Circadian rhythm disruption exacerbates Th2-like immune response in murine allergic airway inflammation.International forum of allergy & rhinology · 2022Article
- Temporal Modulation of Drug Desensitization Procedures.Current issues in molecular biology · 2022Review
- Establishment of a 3-Dimensional Intestinal Cell Model to Simulate the Intestinal Mucosal Immune System for Food Allergy Investigations.Frontiers in immunology · 2022Article
- Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression.Pharmaceutics · 2021Review
- Circadian asthma airway responses are gated by REV-ERBα.The European respiratory journal · 2020Article
- Period2 gene regulates diurnal changes of nasal symptoms in an allergic rhinitis mouse model.International forum of allergy & rhinology · 2020Article
- Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics.British journal of pharmacology · 2020Review
- Crosstalk Among Circadian Rhythm, Obesity and Allergy.International journal of molecular sciences · 2020Review
- Circadian Regulation of the Biology of Allergic Disease: Clock Disruption Can Promote Allergy.Frontiers in immunology · 2020Review
- A selective window after the food-intake period favors tolerance induction in mesenteric lymph nodes.Mucosal immunology · 2019Article
- Diurnal variations in intestinal barrier integrity and liver pathology in mice: implications for alcohol binge.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Nutrition and the circadian system.The British journal of nutrition · 2016Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian circadian clock controls many physiological processes that include immune responses and allergic reactions. Several studies have investigated the circadian regulation of intestinal permeability and tight junctions known to be affected by cytokines. However, the contribution of circadian clock to food allergy symptoms remains unclear. Therefore, we investigated the role of the circadian clock in determining the severity of food allergies. We prepared an ovalbumin food allergy mouse model, and orally administered ovalbumin either late in the light or late in the dark period under light-dark cycle. The light period group showed higher allergic diarrhea and weight loss than the dark period group. The production of type 2 cytokines, IL-13 and IL-5, from the mesenteric lymph nodes and ovalbumin absorption was higher in the light period group than in the dark period group. Compared to the dark period group, the mRNA expression levels of the tight junction proteins were lower in the light period group. We have demonstrated that increased production of type 2 cytokines and intestinal permeability in the light period induced severe food allergy symptoms. Our results suggest that the time of food antigen intake might affect the determination of the severity of food allergy symptoms.
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