Trial reportBMC endocrine disorders2015
Leukocyte telomere length and diabetes status, duration, and control: the 1999-2002 National Health and Nutrition Examination Survey.
Trial report in BMC endocrine disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression.Scientific reports · 2023Article
- Insulin Resistance and Biological Aging: The Role of Body Mass, Waist Circumference, and Inflammation.BioMed research international · 2022Article
- Telomeres and Age-Related Diseases.Biomedicines · 2021Review
- Telomere length in different metabolic categories: Clinical associations and modification potential.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Urinary metals and leukocyte telomere length in American Indian communities: The Strong Heart and the Strong Heart Family Study.Environmental pollution (Barking, Essex : 1987) · 2019Article
- A scoping systematic review of social stressors and various measures of telomere length across the life course.Ageing research reviews · 2018Article
- Possible association of the TERT promoter polymorphisms rs2735940, rs7712562 and rs2853669 with diabetes mellitus in obese elderly Polish population: results from the national PolSenior study.Journal of applied genetics · 2018Article
- The shortening of leukocyte telomere length relates to DNA hypermethylation of LINE-1 in type 2 diabetes mellitus.Oncotarget · 2017Article
- Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage.Scientific reports · 2017Article
- Leukocyte telomere length is inversely associated with post-load but not with fasting plasma glucose levels.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Less Than Ideal Cardiovascular Health Is Associated With Shorter Leukocyte Telomere Length: The National Health and Nutrition Examination Surveys, 1999-2002.Journal of the American Heart Association · 2017Article
- Article
- Shortened leukocyte telomere length in type 2 diabetes mellitus: genetic polymorphisms in mitochondrial uncoupling proteins and telomeric pathways.Clinical and translational medicine · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundStudies investigating the association between telomere length and diabetes have been inconsistent, and there are few data available investigating the associations of telomere length with diabetes duration and control. We evaluated the relationship of leukocyte telomere length with diabetes, and the relationship of leukocyte telomere length with diabetes duration and poor glucose control among people with diabetes.
methodsWe used data from the 1999-2002 National Health and Nutrition Examination Survey, a representative sample of the US civilian non-institutionalized population. In 3921 participants, leukocyte telomere length was measured and diabetes status was determined based on a previous diagnosis, hemoglobin A1c ≥ 6.5 %, or fasting glucose ≥ 126 mg/dL.
resultsThe odds ratios (95 % confidence intervals) of diabetes associated with the first, second, and third quartile of leukocyte telomere length, compared to the highest quartile, was 2.09 (1.46-2.98), 1.74 (1.30-2.31), and 1.08 (0.76-1.54), respectively (p-trend < 0.01), in unadjusted models and 0.74 (0.48-1.14), 0.91 (0.61-1.34), and 0.87 (0.59-1.29), respectively (p-trend = 0.20), in multivariable adjusted models. Among participants with diabetes, unadjusted and adjusted leukocyte telomere length was not associated with diabetes duration or glucose control based on an hemoglobin A1c < 7 or < 8 % (all p > 0.05).
conclusionsIn this study of the US general population, leukocyte telomere length was not associated with diabetes status, diabetes duration, or diabetes control.
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