ArticleOncotarget2015
The effective bioengineering method of implantation decellularized renal extracellular matrix scaffolds.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Current strategies on kidney regeneration using tissue engineering approaches: a systematic review.BMC nephrology · 2025Pooled it
- Decellularized rat tubules for tissue engineering.Translational andrology and urology · 2025Article
- Transplantation of decellularized porcine kidney grafts repopulated with primary human cells demonstrates filtration function in pigs.Communications medicine · 2024Article
- Angiogenesis and Re-endothelialization in decellularized scaffolds: Recent advances and current challenges in tissue engineering.Frontiers in bioengineering and biotechnology · 2023Review
- Intravital microscopy datasets examining key nephron segments of transplanted decellularized kidneys.Scientific data · 2022Article
- Detection of the residual concentration of sodium dodecyl sulfate in the decellularized whole rabbit kidney extracellular matrix.Cell and tissue banking · 2022Article
- Potential Strategies for Kidney Regeneration With Stem Cells: An Overview.Frontiers in cell and developmental biology · 2022Review
- Considerations for the clinical use of stem cells in genitourinary regenerative medicine.World journal of stem cells · 2021Review
- Stem/progenitor cell in kidney: characteristics, homing, coordination, and maintenance.Stem cell research & therapy · 2021Review
- Kidney tissue engineering using a well-preserved acellular rat kidney scaffold and mesenchymal stem cells.Veterinary research forum : an international quarterly journal · 2021Article
- The Renal Extracellular Matrix as a Supportive Scaffold for Kidney Tissue Engineering: Progress and Future Considerations.Advances in experimental medicine and biology · 2021Article
- Sustained perfusion of revascularized bioengineered livers heterotopically transplanted into immunosuppressed pigs.Nature biomedical engineering · 2020Article
- Induced Intermediate Mesoderm Combined with Decellularized Kidney Scaffolds for Functional Engineering Kidney.Tissue engineering and regenerative medicine · 2019Article
- Mesenchymal Stem Cells-Potential Applications in Kidney Diseases.International journal of molecular sciences · 2019Review
- Applications of kidney organoids derived from human pluripotent stem cells.The Korean journal of internal medicine · 2018Review
- Amniotic fluid cells: current progress and emerging challenges in renal regeneration.Pediatric nephrology (Berlin, Germany) · 2018Review
- Tissue engineering for urinary tract reconstruction and repair: Progress and prospect in China.Asian journal of urology · 2018Review
- Experimental Evaluation of Kidney Regeneration by Organ Scaffold Recellularization.Scientific reports · 2017Article
- Advances in the Knowledge about Kidney Decellularization and Repopulation.Frontiers in bioengineering and biotechnology · 2017Review
- Repopulating Decellularized Kidney Scaffolds: An Avenue forMaterials (Basel, Switzerland) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
End stage renal disease (ESRD) is a progressive loss of kidney function with a high rate of morbidity and mortality. Transplantable organs are hard to come by and hold a high risk of recipient immune rejection. We intended to establish a more effective and faster method to decellularize and recellularize the kidney scaffold for transplant and regeneration. We successfully produced renal scaffolds by decellularizing rat kidneys with 0.5% sodium dodecyl sulfate (SDS), while still preserving the extracellular matrix (ECM) 3D architecture, an intact vascular tree and biochemical components. We recellularized the kidney scaffolds with mouse embryonic stem (ES) cells that then populated and proliferated within the glomerular, vascular, and tubular structures. After in vivo implantation, these recellularized scaffolds were easily reperfused, tolerated blood pressure and produced urine with no blood leakage. Our methods can successfully decellularize and recellularize rat kidneys to produce functional renal ECM scaffolds. These scaffolds maintain their basic components, retain intact vasculature and show promise for kidney regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.