ArticleNature methods2015
What if stem cells turn into embryos in a dish?
Article in Nature methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature.Stem cell research & therapy · 2023Pooled it
- Organoids: a systematic review of ethical issues.Stem cell research & therapy · 2022Pooled it
- A guide to using embedded ethics in human stem-cell-based embryo model research.Nature cell biology · 2026Review
- Three-Dimensional Models of Implantation Using Human Stem Cells: Scientific Insights and Broader Considerations.Biomolecules · 2025Review
- 'Ceci n'est pas un embryon?' The ethics of human embryo model research.Nature methods · 2023Article
- Knowledge graphs of ethical concerns of cerebral organoids.Cell proliferation · 2022Article
- Patients' perspectives on the derivation and use of organoids.Stem cell reports · 2021Article
- Ethical Challenges in Organoid Use.Biotech (Basel (Switzerland)) · 2021Article
- Review
- Biomedical and societal impacts of in vitro embryo models of mammalian development.Stem cell reports · 2021Review
- Human Embryo Models and Drug Discovery.International journal of molecular sciences · 2021Review
- Avoiding the potentiality trap: thinking about the moral status of synthetic embryos.Monash bioethics review · 2020Article
- Embryo experimentation: is there a case for moving beyond the '14-day rule'.Monash bioethics review · 2020Article
- Human cerebral organoids and consciousness: a double-edged sword.Monash bioethics review · 2020Article
- The moral status of human embryo-like structures: potentiality matters?: The moral status of human synthetic embryos.EMBO reports · 2020Article
- Canada'sFrontiers in medicine · 2019Article
- Debate ethics of embryo models from stem cells.Nature · 2018Article
- Progress and potential in organoid research.Nature reviews. Genetics · 2018Review
- Responsible innovation in human germline gene editing: Background document to the recommendations of ESHG and ESHRE.European journal of human genetics : EJHG · 2018Article
- Research on Human Embryos and Reproductive Materials: Revisiting Canadian Law and Policy.Healthcare policy = Politiques de sante · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Recent studies show that pluripotent stem cells can undergo self-organized development in vitro into structures that mimic the body plan of the post-implantation embryo. Modeling human embryogenesis in a dish opens up new possibilities for the study of early development and developmental disorders, but it may also raise substantial ethical concerns.
Indexed as
Identifiers
26418764What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.