ArticleNature communications2015
A recursive vesicle-based model protocell with a primitive model cell cycle.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed.
- Bottom-Up Coacervate-Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life-Like Systems.Angewandte Chemie (International ed. in English) · 2026Review
- Repetitive temperature cycles with DMSO sustain RNA replicating liposome compartments via fusion mediated content exchange.Communications biology · 2026Article
- Synthetic dynamic transcription frameworks and their applications.Nature chemistry · 2026Review
- Analysis of Inner Content and Phospholipid Membrane Fusion during Two Step Freezing Induced Liposome Fusion.ACS omega · 2026Article
- Composition dependent effects of charged lipids on freeze-thaw induced fusion in dioleoyl phospholipid membranes.Biophysics and physicobiology · 2026Article
- Orchestrating Self-Replication in Artificial Cells with Digital Microfluidics.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Enhanced enzyme stability at the interphase of water-oil for continuous-flow olefin epoxidation.Nature communications · 2025Article
- Interfacial assembly of biomimetic MOF-based porous membranes on coacervates to build complex protocells and prototissues.Nature chemistry · 2025Article
- Photochemical synthesis of natural lipids in artificial and living cells.Nature communications · 2025Article
- Adaptive ATP-induced molecular condensation in membranized protocells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Selective peptide bond formation via side chain reactivity and self-assembly of abiotic phosphates.Nature communications · 2025Article
- Chemically Driven Division of Protocells by Membrane Budding.Journal of the American Chemical Society · 2024Article
- Protocell Effects on RNA Folding, Function, and Evolution.Accounts of chemical research · 2024Article
- The Evolutionary Transition of the RNA World to Obcells to Cellular-Based Life.Journal of molecular evolution · 2024Article
- Article
- Autonomic Integration in Nested Protocell Communities.Journal of the American Chemical Society · 2023Article
- Article
- Dynamic Transcription Machineries Guide the Synthesis of Temporally Operating DNAzymes, Gated and Cascaded DNAzyme Catalysis.ACS nano · 2023Article
- Evolution of Proliferative Model Protocells Highly Responsive to the Environment.Life (Basel, Switzerland) · 2022Review
- Modulating membrane fusion through the design of fusogenic DNA circuits and bilayer composition.Soft matter · 2022Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-organized lipid structures (protocells) have been proposed as an intermediate between nonliving material and cellular life. Synthetic production of model protocells can demonstrate the potential processes by which living cells first arose. While we have previously described a giant vesicle (GV)-based model protocell in which amplification of DNA was linked to self-reproduction, the ability of a protocell to recursively self-proliferate for multiple generations has not been demonstrated. Here we show that newborn daughter GVs can be restored to the status of their parental GVs by pH-induced vesicular fusion of daughter GVs with conveyer GVs filled with depleted substrates. We describe a primitive model cell cycle comprising four discrete phases (ingestion, replication, maturity and division), each of which is selectively activated by a specific external stimulus. The production of recursive self-proliferating model protocells represents a step towards eventual production of model protocells that are able to mimic evolution.
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