ArticleAnesthesiology2015
Fiber-optic Monitoring of Spinal Cord Hemodynamics in Experimental Aortic Occlusion.
Article in Anesthesiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 25 citations in OpenAlex.
- Compact FPGA-based software correlator for real-time blood flow measurement with diffuse correlation spectroscopy.Biomedical optics express · 2026Article
- Comparing multi- and single-exposure speckle contrast optical spectroscopy methods as estimators of blood flow in the diffuse regime.Journal of biomedical optics · 2026Article
- Whole body measurements using near-infrared spectroscopy in a rat spinal cord contusion injury model.The journal of spinal cord medicine · 2023Article
- Dual-Polarization Bandwidth-Bridged Bandpass Sampling Fourier Transform Spectrometer from Visible to Near-Infrared on a Silicon Nitride Platform.ACS photonics · 2022Article
- Optical imaging and spectroscopy for the study of the human brain: status report.Neurophotonics · 2022Article
- Intraoperative Optical Monitoring of Spinal Cord Hemodynamics Using Multiwavelength Imaging System.Sensors (Basel, Switzerland) · 2022Article
- Lossless Compressed Sensing of Photon Counts for Fast Diffuse Correlation Spectroscopy.IEEE access : practical innovations, open solutions · 2022Article
- Fast diffuse correlation spectroscopy with a low-cost, fiber-less embedded diode laser.Biomedical optics express · 2021Article
- Towards rapid intraoperative axial localization of spinal cord ischemia with epidural diffuse correlation monitoring.PloS one · 2021Article
- Multi-Site Optical Monitoring of Spinal Cord Ischemia during Spine Distraction.Journal of neurotrauma · 2020Article
- Transcutaneous contrast-enhanced ultrasound imaging of the posttraumatic spinal cord.Spinal cord · 2020Article
- Spinal cord autoregulation using near-infrared spectroscopy under normal, hypovolemic, and post-fluid resuscitation conditions in a swine model: a comparison with cerebral autoregulation.Journal of intensive care · 2020Article
- Monitoring spinal cord hemodynamics and tissue oxygenation: a review of the literature with special focus on the near-infrared spectroscopy technique.Spinal cord · 2019Review
- Diffuse Correlation Spectroscopy Analysis Implemented on a Field Programmable Gate Array.IEEE access : practical innovations, open solutions · 2019Article
- Laser safety in fiber-optic monitoring of spinal cord hemodynamics: a preclinical evaluation.Journal of biomedical optics · 2018Article
- Validation of diffuse correlation spectroscopy sensitivity to nicotinamide-induced blood flow elevation in the murine hindlimb using the fluorescent microsphere technique.Journal of biomedical optics · 2018Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundSpinal cord ischemia occurs frequently during thoracic aneurysm repair. Current methods based on electrophysiology techniques to detect ischemia are indirect, non-specific, and temporally slow. In this article, the authors report the testing of a spinal cord blood flow and oxygenation monitor, based on diffuse correlation and optical spectroscopies, during aortic occlusion in a sheep model.
methodsTesting was carried out in 16 Dorset sheep. Sensitivity in detecting spinal cord blood flow and oxygenation changes during aortic occlusion, pharmacologically induced hypotension and hypertension, and physiologically induced hypoxia/hypercarbia was assessed. Accuracy of the diffuse correlation spectroscopy measurements was determined via comparison with microsphere blood flow measurements. Precision was assessed through repeated measurements in response to pharmacologic interventions.
resultsThe fiber-optic probe can be placed percutaneously and is capable of continuously measuring spinal cord blood flow and oxygenation preoperatively, intraoperatively, and postoperatively. The device is sensitive to spinal cord blood flow and oxygenation changes associated with aortic occlusion, immediately detecting a decrease in blood flow (-65 ± 32%; n = 32) and blood oxygenation (-17 ± 13%, n = 11) in 100% of trials. Comparison of spinal cord blood flow measurements by the device with microsphere measurements led to a correlation of R = 0.49, P < 0.01, and the within-sheep coefficient of variation was 9.69%. Finally, diffuse correlation spectroscopy is temporally more sensitive to ischemic interventions than motor-evoked potentials.
conclusionThe first-generation spinal fiber-optic monitoring device offers a novel and potentially important step forward in the monitoring of spinal cord ischemia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.