ArticleEpigenomics2015
Altered miRNA expression in the cervix during pregnancy associated with lead and mercury exposure.
Article in Epigenomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- 'Omics in environmental epidemiological studies of chemical exposures: A systematic evidence map.Environment international · 2022Pooled it
- A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysis.Frontiers in public health · 2022Pooled it
- Association of maternal blood mercury concentration during the first trimester of pregnancy with birth outcomes.Scientific reports · 2024Article
- Blood lead levels in pregnant women and their newborn infants at an Indian teaching hospital.Journal of family medicine and primary care · 2024Article
- The interaction between miRNAs and hazardous materials.Non-coding RNA research · 2023Review
- Cervical microRNA expression and spontaneous preterm birth.American journal of obstetrics & gynecology MFM · 2023Article
- Article
- Urinary metals and maternal circulating extracellular vesicle microRNA in the MADRES pregnancy cohort.Epigenetics · 2022Article
- Extracellular vesicle microRNA in early versus late pregnancy with birth outcomes in the MADRES study.Epigenetics · 2022Article
- Prenatal blood lead levels and reduced preadolescent glomerular filtration rate: Modification by body mass index.Environment international · 2021Article
- Exposure to toxic metals and per- and polyfluoroalkyl substances and the risk of preeclampsia and preterm birth in the United States: a review.American journal of obstetrics & gynecology MFM · 2021Review
- MicroRNA (miRNA) Differential Expression and Exposure to Crude-Oil- Related Compounds.MicroRNA (Shariqah, United Arab Emirates) · 2021Review
- Developmental exposure to methylmercury and ADHD, a literature review of epigenetic studies.Environmental epigenetics · 2021Review
- Role of non-coding-RNAs in response to environmental stressors and consequences on human health.Redox biology · 2020Review
- Epigenetic Basis of Lead-Induced Neurological Disorders.International journal of environmental research and public health · 2020Review
- Pregnancy-associated changes in cervical noncoding RNA.Epigenomics · 2020Article
- The role of environmental exposures and the epigenome in health and disease.Environmental and molecular mutagenesis · 2020Review
- Long-Term Exercise Alters the Profiles of Circulating Micro-RNAs in the Plasma of Young Women.Frontiers in physiology · 2020Article
- MicroRNAs and Xenobiotic Toxicity: An Overview.Toxicology reports · 2020Review
- Genomic Tools for Environmental Epigenetics and Implications for Public Health.Current opinion in toxicology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
aimToxic metals including lead and mercury are associated with adverse pregnancy outcomes. This study aimed to assess the association between miRNA expression in the cervix during pregnancy with lead and mercury levels. MATERIALS &
methodsWe obtained cervical swabs from pregnant women (n = 60) and quantified cervical miRNA expression. Women's blood lead, bone lead and toenail mercury levels were analyzed. We performed linear regression to examine the association between metal levels and expression of 74 miRNAs adjusting for covariates.
resultsSeventeen miRNAs were negatively associated with toenail mercury levels, and tibial bone lead levels were associated with decreased expression of miR-575 and miR-4286.
conclusionThe findings highlight miRNAs in the human cervix as novel responders to maternal chemical exposure during pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.