Evidence map›Paper›PMID 26418604›Full record

GuidelinePediatric pulmonology2016

Diagnosis, monitoring, and treatment of primary ciliary dyskinesia: PCD foundation consensus recommendations based on state of the art review.

Adam J Shapiro, Maimoona A Zariwala, Thomas Ferkol, Stephanie D Davis, Scott D Sagel, Sharon D Dell, Margaret Rosenfeld, Kenneth N Olivier, Carlos Milla, Sam J Daniel and 5 more

4 registry-linked trialsOpen access · bronzeAbstract readConsensus StatementPractice GuidelineReview
In one paragraph

Guideline in Pediatric pulmonology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 215 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
215citing papers in PubMed, 5 pooled it
22.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02704455 not yet recruitingnot on this map

Registry Study on Primary Ciliary Dyskinesia in Chinese children-a Multicenter, Prospective Cohort Study

TypeobservationalSponsorBeijing Children's HospitalRan2016 to 2030Enrolled100ConditionsPrimary Ciliary Dyskinesia
NCT05287022 recruitingnot on this mapstarted 2021, after this paper: background citation

Use of Nasal Nitric Oxide Testing in Improving Primary Ciliary Dyskinesia Clinical Care

TypeobservationalSponsorArkansas Children's Hospital Research InstituteRan2021 to 2030Enrolled150ConditionsPrimary Ciliary Dyskinesia
NCT06959251 narecruitingnot on this mapstarted 2025, after this paper: background citation

A Randomized, Placebo-controlled Clinical Trial Evaluating the Efficacy and Safety of Glycine and Magnesium+Thiamine Supplements, Alone or Combined, Administered for 6 Months to Patients With Primary Ciliary Dyskinesia

TypeinterventionalSponsorInstituto Nacional de Enfermedades RespiratoriasRan2025 to 2028Enrolled60ConditionsPrimary Ciliary DyskinesiaArmsGlycine, Magnesium+thiamine, Placebo
NCT07566611 narecruitingnot on this mapstarted 2026, after this paper: background citation

Novel Use of Combined High-Speed Video Microscopy and Nasal Nitric Oxide Screening for Identification of Primary Ciliary Dyskinesia in Adult Bronchiectasis

TypeinterventionalSponsorIndiana UniversityRan2026 to 2028Enrolled60ConditionsIdiopathic BronchiectasisArmsNasal Nitric Oxide Measurement, Nasopharyngeal (Nasal) Samples
3 · Its place in the literature

Who cites it

215 citing papers in PubMed, 5 syntheses or guidelines pooled it, 435 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. The patient's experience of primary ciliary dyskinesia: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017
    Pooled it
  5. Pooled it
  6. Trial
  7. Article
  8. Pulmonary exacerbations in primary ciliary dyskinesia.European journal of pediatrics · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

155 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 2 countries.

Adam J ShapiroDepartment of Pediatrics, Montreal Children's Hospital, McGill University, Quebec, Canada.
Maimoona A ZariwalaDepartment of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Marsico Lung Institute, Chapel Hill, North Carolina.
Thomas FerkolDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Stephanie D DavisDepartment of Pediatrics, Riley Hospital for Children, Indiana University, Indianapolis, Indiana.
Scott D SagelDepartment of Pediatrics, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, Colorado.
Sharon D DellDepartment of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Margaret RosenfeldDepartment of Pediatrics, Seattle Children's Hospital and University of Washington, Seattle, Washington.
Kenneth N OlivierNational Heart, Lung, and Blood Institute, Bethesda, Maryland.
Carlos MillaDepartment of Pediatrics, Stanford University, Palo Alto, California.
Sam J DanielDepartment of Otolaryngology, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.
Adam J KimpleDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Michele ManionThe PCD Foundation-President, Minneapolis, Minnesota.
Michael R KnowlesDepartment of Medicine, University of North Carolina, Marsico Lung Institute, Chapel Hill, North Carolina.
Margaret W LeighDepartment of Pediatrics, University of North Carolina, Marsico Lung Institute, Chapel Hill, North Carolina.
Genetic Disorders of Mucociliary Clearance Consortium
Lung Institute · USUniversity of North Carolina at Chapel Hill · USCOPD Foundation · USIndiana University – Purdue University Indianapolis · USMcGill University · CAMontreal Children's Hospital · CANational Heart Lung and Blood Institute · USSickKids Foundation · CAStanford University · USUniversity of Colorado Denver · USUniversity of Washington · USWashington University in St. Louis · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Bronchiectasis and chronic airway infectionZIAHL006200 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI FENNELLY, KEVIN · 2015 to 2025
$25.1M
Colorado Clinical and Translational Science Institute (UL1)UL1TR000154 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$20.4M
Longitudinal Characterization of Respiratory Tract Exacerbations and Treatment Responses in Primary Ciliary DyskinesiaU54HL096458 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DELL, SHARON · 2009 to 2023
$20.0M
Pathogenesis of PCD Lung DiseaseR01HL071798 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KNOWLES, MICHAEL R · 2004 to 2021
$7.2M
Intramural NIH HHSNCATS NIH HHS UL1 TR000154NCATS NIH HHS UL1TR000154NCATS NIH HHS UL1 TR001082NHLBI NIH HHS 5R01HL071798NHLBI NIH HHS R01 HL071798NHLBI NIH HHS U54 HL096458NHLBI NIH HHS U54HL096458PHS HHS ULTR000083
6 · The paper itself

Abstract

Primary ciliary dyskinesia (PCD) is a genetically heterogeneous, rare lung disease resulting in chronic oto-sino-pulmonary disease in both children and adults. Many physicians incorrectly diagnose PCD or eliminate PCD from their differential diagnosis due to inexperience with diagnostic testing methods. Thus far, all therapies used for PCD are unproven through large clinical trials. This review article outlines consensus recommendations from PCD physicians in North America who have been engaged in a PCD centered research consortium for the last 10 years. These recommendations have been adopted by the governing board of the PCD Foundation to provide guidance for PCD clinical centers for diagnostic testing, monitoring, and appropriate short and long-term therapeutics in PCD patients.

Indexed as

BiopsyBreath TestsChronic DiseaseDisease ManagementGenetic TestingHumansInfluenza VaccinesKartagener SyndromeMicroscopy, ElectronMicroscopy, VideoNorth AmericaPneumococcal VaccinesRespiratory Syncytial Virus VaccinesRespiratory TherapyInfluenza VaccinesPneumococcal VaccinesRespiratory Syncytial Virus Vaccinesconsensus statementPCD FoundationPCD, kartagenerprimary ciliary dyskinesia

Identifiers

PMID26418604
PMCPMC4912005
OpenAlexW2142218173

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.