ArticlePloS one2015
Altered Right Ventricular Kinetic Energy Work Density and Viscous Energy Dissipation in Patients with Pulmonary Arterial Hypertension: A Pilot Study Using 4D Flow MRI.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical applications of intra-cardiac four-dimensional flow cardiovascular magnetic resonance: A systematic review.International journal of cardiology · 2017Pooled it
- Multimodal Framework of Left Heart-Pulmonary Vascular Remodeling Underlying Right Ventricular Failure in PH-HFpEF.Circulation. Heart failure · 2026Article
- Right heart flow hemodynamic assessment using 4D flow CMR: a systematic review.European heart journal. Imaging methods and practice · 2025Review
- Right Heart Failure in Critical and Chronic Care: Current Concepts, Challenges and Mechanical Support Strategies.Medical sciences (Basel, Switzerland) · 2025Review
- Increased contractility affects left ventricular kinetic energy in pulmonary hypertension.Physiological reports · 2025Observational
- A Non-Invasive Approach to Pulmonary Hypertension.Journal of clinical medicine · 2025Review
- Assessment of aortic hemodynamics in patients with thoracoabdominal aortic aneurysm using four-dimensional magnetic resonance imaging: a cross-sectional study.Quantitative imaging in medicine and surgery · 2024Article
- Robotic right ventricle is a biohybrid platform that simulates right ventricular function in (patho)physiological conditions and intervention.Nature cardiovascular research · 2023Article
- Effects of ranolazine on right ventricular function, fluid dynamics, and metabolism in patients with precapillary pulmonary hypertension: insights from a longitudinal, randomized, double-blinded, placebo controlled, multicenter study.Frontiers in cardiovascular medicine · 2023Article
- Blood flow kinetic energy is a novel marker for right ventricular global systolic function in patients with left ventricular assist device therapy.Frontiers in cardiovascular medicine · 2023Article
- Right ventricular energetic biomarkers from 4D Flow CMR are associated with exertional capacity in pulmonary arterial hypertension.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022Article
- Hemodynamic Parameters for Cardiovascular System in 4D Flow MRI: Mathematical Definition and Clinical Applications.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- Advances in machine learning applications for cardiovascular 4D flow MRI.Frontiers in cardiovascular medicine · 2022Review
- Assessment of ventricular flow dynamics by 4D-flow MRI in patients following surgical repair of d-transposition of the great arteries.European radiology · 2021Article
- Role of cardiovascular magnetic resonance in pediatric pulmonary hypertension-novel concepts and imaging biomarkers.Cardiovascular diagnosis and therapy · 2021Review
- Altered Right Ventricular Filling at Four-dimensional Flow MRI in Young Adults Born Prematurely.Radiology. Cardiothoracic imaging · 2021Article
- Short-Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4-Dimensional-Flow Magnetic Resonance Imaging in Children With Pulmonary Arterial Hypertension.Journal of the American Heart Association · 2021Article
- MR 4D flow-based mean pulmonary arterial pressure tracking in pulmonary hypertension.European radiology · 2021Article
- From Early Morphometrics to Machine Learning-What Future for Cardiovascular Imaging of the Pulmonary Circulation?Diagnostics (Basel, Switzerland) · 2020Review
- Sex Differences in Cardiac Flow Dynamics of Healthy Volunteers.Radiology. Cardiothoracic imaging · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRight ventricular (RV) function has increasingly being recognized as an important predictor for morbidity and mortality in patients with pulmonary arterial hypertension (PAH). The increased RV after-load increase RV work in PAH. We used time-resolved 3D phase contrast MRI (4D flow MRI) to derive RV kinetic energy (KE) work density and energy loss in the pulmonary artery (PA) to better characterize RV work in PAH patients.
methods4D flow and standard cardiac cine images were obtained in ten functional class I/II patients with PAH and nine healthy subjects. For each individual, we calculated the RV KE work density and the amount of viscous dissipation in the PA.
resultsPAH patients had alterations in flow patterns in both the RV and the PA compared to healthy subjects. PAH subjects had significantly higher RV KE work density than healthy subjects (94.7±33.7 mJ/mL vs. 61.7±14.8 mJ/mL, p = 0.007) as well as a much greater percent PA energy loss (21.1±6.4% vs. 2.2±1.3%, p = 0.0001) throughout the cardiac cycle. RV KE work density and percent PA energy loss had mild and moderate correlations with RV ejection fraction.
conclusionThis study has quantified two kinetic energy metrics to assess RV function using 4D flow. RV KE work density and PA viscous energy loss not only distinguished healthy subjects from patients, but also provided distinction amongst PAH patients. These metrics hold promise as imaging markers for RV function.
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