Evidence map›Paper›PMID 26418471›Full record

ArticleRegenerative medicine2015

Microsphere-based gradient implants for osteochondral regeneration: a long-term study in sheep.

Neethu Mohan, Vineet Gupta, Banu Priya Sridharan, Adam J Mellott, Jeremiah T Easley, Ross H Palmer, Richard A Galbraith, Vincent H Key, Cory J Berkland, Michael S Detamore

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. A bioactive supramolecular and covalent polymer scaffold for cartilage repair in a sheep model.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Scaffold-Based Tissue Engineering Strategies for Osteochondral Repair.Frontiers in bioengineering and biotechnology · 2021
    Review
  12. Review
  13. Animal Models of Osteochondral Defect for Testing Biomaterials.Biochemistry research international · 2020
    Review
  14. Review
  15. Article
  16. Review
  17. Microsphere-Based Scaffolds in Regenerative Engineering.Annual review of biomedical engineering · 2017
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Neethu MohanDepartment of Chemical & Petroleum Engineering, University of Kansas, Lawrence, KS 66045, USA.
Vineet GuptaBioengineering Graduate Program, University of Kansas, Lawrence, KS 66045, USA.
Banu Priya SridharanBioengineering Graduate Program, University of Kansas, Lawrence, KS 66045, USA.
Adam J MellottDepartment of Chemical & Petroleum Engineering, University of Kansas, Lawrence, KS 66045, USA.
Jeremiah T EasleyPreclinical Surgical Research Laboratory, College of Veterinary Medicine & Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Ross H PalmerPreclinical Surgical Research Laboratory, College of Veterinary Medicine & Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Richard A GalbraithLawrence Memorial Hospital, Lawrence, KS 66044, USA.
Vincent H KeyUniversity of Kansas Medical Center, Kansas City, KS 66160, USA.
Cory J BerklandDepartment of Chemical & Petroleum Engineering, University of Kansas, Lawrence, KS 66045, USA.
Michael S DetamoreDepartment of Chemical & Petroleum Engineering, University of Kansas, Lawrence, KS 66045, USA.
University of Kansas · USColorado State University · USMemorial Hospital · USUniversity of Kansas Medical Center · US

Funding

Gradient-based strategy for osteochondral regenerationR01AR056347 · NIAMS · UNIVERSITY OF KANSAS LAWRENCE · PI DETAMORE, MICHAEL S. · 2010 to 2014
$1.3M
NIAMS NIH HHS R01 AR056347
6 · The paper itself

Abstract

backgroundThe microfracture technique for cartilage repair has limited ability to regenerate hyaline cartilage.

aimThe current study made a direct comparison between microfracture and an osteochondral approach with microsphere-based gradient plugs. MATERIALS &

methodsThe PLGA-based scaffolds had opposing gradients of chondroitin sulfate and β-tricalcium phosphate. A 1-year repair study in sheep was conducted.

resultsThe repair tissues in the microfracture were mostly fibrous and had scattered fissures with degenerative changes. Cartilage regenerated with the gradient plugs had equal or superior mechanical properties; had lacunated cells and stable matrix as in hyaline cartilage.

conclusionThis first report of gradient scaffolds in a long-term, large animal, osteochondral defect demonstrated potential for equal or better cartilage repair than microfracture.

Indexed as

MicrospheresAnimalsBone and BonesCalcium PhosphatesCartilage, ArticularChondrocytesChondroitin SulfatesFemaleFemurFinite Element AnalysisHumansHyaline CartilageInflammationKnee JointLactic AcidMagnetic Resonance Imagingbeta-tricalcium phosphateCalcium PhosphatesChondroitin SulfatesLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerTransforming Growth Factor betacartilage regenerationchondroitin sulfategradients of signalsmicrofracturemicrosphere-based scaffoldosteochondral tissue engineering

Identifiers

PMID26418471
PMCPMC4977000
OpenAlexW2099425922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.