ArticlePLoS genetics2015
Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Pathogenic KIF1A variants differentially disrupt axonal trafficking and impede synaptic development.The Journal of cell biology · 2026Article
- Pathogenic KIF1A variants differentially disrupt axonal trafficking and impede synaptic development.bioRxiv : the preprint server for biology · 2026Article
- A comprehensive genome-wide analysis for signatures of selection in goat (genus Capra) revealed new candidate genes for environmental adaptation and productive traits.BMC genomics · 2025Article
- Technical Considerations for Detecting Protein-Protein Interactions Using Proximity Ligation Assay.Journal of proteome research · 2025Article
- Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling.bioRxiv : the preprint server for biology · 2024Article
- Region-specific reversal of epidermal planar polarity in the rosette fancy mouse.Development (Cambridge, England) · 2023Article
- Analysis of Copy Number Variation in the Whole Genome of Normal-Haired and Long-Haired Tianzhu White Yaks.Genes · 2022Article
- Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development.Development (Cambridge, England) · 2022Article
- Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice.Genome biology · 2022Article
- Global feather orientations changed by electric current.iScience · 2021Article
- Murine astrotactins 1 and 2 have a similar membrane topology and mature via endoproteolytic cleavage catalyzed by a signal peptidase.The Journal of biological chemistry · 2019Article
- Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation.International journal of biological sciences · 2019Article
- Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles.Development (Cambridge, England) · 2018Article
- Repurposing a pore: highly conserved perforin-like proteins with alternative mechanisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns.Developmental biology · 2017Article
- Intramembrane Proteolysis of Astrotactins.The Journal of biological chemistry · 2017Article
- Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development.Open biology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Planar cell polarity (PCP) signaling controls the global orientation of surface structures, such as hairs and bristles, in both vertebrates and invertebrates. In Frizzled6(-/-) (Fz6(-/-)) mice, hair follicle orientations on the head and back are nearly random at birth, but reorient during early postnatal development to eventually generate a nearly parallel anterior-to-posterior array. We report the identification of a naturally occurring exon 5 deletion in Astrotactin2 (Astn2) that acts as a recessive genetic modifier of the Fz6(-/-) hair patterning phenotype. A genetically engineered Astn2 exon 5 deletion recapitulates the modifier phenotype. In Fz6(-/-);Astn2(ex5del/del) mice, hair orientation on the back is subtly biased from posterior-to-anterior, leading to a 180-degree orientation reversal in mature mice. These experiments suggest that Astn2, an endosomal membrane protein, modulates PCP signaling.
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