ArticlePloS one2015
Comprehensive Identification of Sexual Dimorphism-Associated Differentially Expressed Genes in Two-Way Factorial Designed RNA-Seq Data on Japanese Quail (Coturnix coturnix japonica).
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 15 citations in OpenAlex.
- Tissue-specific reference gene stability for qPCR in thermally conditioned quail embryos.Biological research · 2026Article
- Dietary arginine modulates egg production and mTOR signalling pathway gene expression in adult Japanese quail (Veterinary and animal science · 2026Article
- Arginine shapes growth and mTOR pathway gene expression in Japanese quails (Coturnix japonica).Scientific reports · 2025Article
- RNA sequencing analysis of sexual dimorphism in Japanese quail.Frontiers in veterinary science · 2024Article
- Estrogen mediates sex differences in preoptic neuropeptide and pituitary hormone production in medaka.Communications biology · 2021Article
- Alternative Animal Models of Aging Research.Frontiers in molecular biosciences · 2021Review
- Prediction and optimization of slaughter weight in meat-type quails using artificial neural network modeling.Poultry science · 2020Article
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- Genes linked to species diversity in a sexually dimorphic communication signal in electric fish.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Japanese quail (Coturnix coturnix japonica) reach sexual maturity earlier, breed rapidly and successfully, and cost less and require less space than other birds raised commercially. Given the value of this species for food production and experimental use, more studies are necessary to determine chromosomal regions and genes associated with gender and breed-differentiation. This study employed Trinity and edgeR for transcriptome analysis of next-generation RNA-seq data, which included 4 tissues obtained from 3 different breeding lines of Japanese quail (random bred control, heavy weight, low weight). Differentially expressed genes shared between female and male tissue contrast groups were analyzed to identify genes related to sexual dimorphism as well as potential novel candidate genes for molecular sexing. Several of the genes identified in the present study as significant sex-related genes have been previously found in avian gene expression analyses (NIPBL, UBAP2), and other genes found differentially expressed in this study and not previously associated with sex-related differences may be considered potential candidates for molecular sexing (TERA, MYP0, PPR17, CASQ2). Additionally, other genes likely associated with neuronal and brain development (CHKA, NYAP), as well as body development and size differentiation (ANKRD26, GRP87) in quail were identified. Expression of homeobox protein regulating genes (HXC4, ISL1) shared between our two sex-related contrast groups (Female Brain vs. Male Brain and Ovary vs. Testis) indicates that these genes may regulate sex-specific anatomical development. Results reveal genetic features of the quail breed and could allow for more effective molecular sexing as well as selective breeding for traits important in commercial production.
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