ReviewCurrent opinion in pediatrics2015
Epigenetics in allergic diseases.
Review in Current opinion in pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bidirectional association between atopic dermatitis and attention deficit hyperactivity disorder: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Decoding Allergic Conjunctivitis: Latest Perspectives on Etiological Drivers and Immunopathological Mechanisms.Clinical reviews in allergy & immunology · 2025Review
- Differential DNA methylation in infants with IgE- and non-IgE-mediated cow's milk allergy and its association with acquired tolerance.Frontiers in immunology · 2025Article
- Comparison of the Concordance of Allergic Diseases between Monozygotic and Dizygotic Twins: A Cross-Sectional Study Using KoGES HTS Data.Journal of personalized medicine · 2023Article
- TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes.Cell & bioscience · 2022Article
- Chronic allergy signaling: is it all stressed-out mitochondria?Faculty reviews · 2022Review
- Maternal atopy and offspring epigenome-wide methylation signature.Epigenetics · 2021Article
- Comparing DNA methylation profiles across different tissues associated with the diagnosis of pediatric asthma.Scientific reports · 2020Article
- Epigenetic studies and pediatric research.Pediatric research · 2020Review
- Understanding the Link Between Allergy and Neurodevelopmental Disorders: A Current Review of Factors and Mechanisms.Frontiers in neurology · 2020Review
- Article
- Epigenetic Modifications in Placenta are Associated with the Child's Sensitization to Allergens.BioMed research international · 2019Article
- Epigenetic Regulation via Altered Histone Acetylation Results in Suppression of Mast Cell Function and Mast Cell-Mediated Food Allergic Responses.Frontiers in immunology · 2018Article
- Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers.The Journal of allergy and clinical immunology · 2017Article
- Article
- Neonatal Immune State Is Influenced by Maternal Allergic Rhinitis and Associated With Regulatory T cells.Allergy, asthma & immunology research · 2017Article
- Effects of a parental exposure to diuron on Pacific oyster spat methylome.Environmental epigenetics · 2017Article
- Establishing a birth cohort to investigate the course and aetiology of asthma and allergies across three generations - rationale, design, and methods of the ACROSSOLAR study.BMC public health · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewAllergic diseases are among the most prevalent chronic diseases of childhood, affecting more than 7 million children in the United States. Epidemiological evidence supports the idea that the inception of allergic diseases is typically before the preschool years, even when chronic symptoms do not emerge until adulthood. The role of epigenetic mechanisms (particularly DNA methylation) in allergic disease is under active investigation because these mechanisms are known to be at the interface of gene regulation, environmental stimuli, and developmental processes, all of which are essential for the pathogenesis for asthma and allergy. This article specifically reviews genome-wide DNA methylation studies in allergic disease. RECENT
findingsDifferential DNA methylation at specific regions appears to be associated with concurrent allergic disease. A few studies have identified methylation signatures predictive of disease. SUMMARY: DNA methylation signatures have been shown to be associated with several allergic disease phenotypes, typically concurrently with disease. The few that have been found to precede diagnosis are especially interesting because they highlight an early trajectory to disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.