Evidence map›Paper›PMID 26418066›Full record

ArticleCancer biology & therapy2015

An exceptional overall survival using bevacizumab beyond progression in a patient with non-small cell lung cancer.

Giandomenico Roviello, Edoardo Francini, Armando Perrella, Letizia Laera, Maria Antonietta Mazzei, Susanna Guerrini, Roberto Petrioli

Abstract readCase Reports
In one paragraph

Article in Cancer biology & therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giandomenico Rovielloa Medical Oncology Unit; University of Siena ; Siena , Italy.
Edoardo Francinib Medical Oncology Unit; Policlinico Umberto I Hospital; University of Rome ; Roma , Italy.
Armando Perrellaa Medical Oncology Unit; University of Siena ; Siena , Italy.
Letizia Laeraa Medical Oncology Unit; University of Siena ; Siena , Italy.
Maria Antonietta Mazzeic Department of Medical ; Surgical and Neurosciences; Diagnostic Imaging; University of Siena ; Siena , Italy.
Susanna Guerrinic Department of Medical ; Surgical and Neurosciences; Diagnostic Imaging; University of Siena ; Siena , Italy.
Roberto Petriolia Medical Oncology Unit; University of Siena ; Siena , Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) is the most common malignancy and the leading cause of cancer death worldwide. In this report, we describe a patient with NSCLC who was treated with continuation of Bevacizumab (Bev) beyond progression to first-line Bev-based chemotherapy. The prolonged treatment with Bev by continuing the inhibition of VEGF beyond first-progression has a strong rationale. Nevertheless, few data exist regarding the efficacy and safety of Bev beyond first line of chemotherapy progression in NSCLC patients. Further studies including a large number of patients are needed, in order to select patients who could benefit from this approach.

Indexed as

Angiogenesis InhibitorsAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsBevacizumabCarcinoma, Non-Small-Cell LungDisease ProgressionFatal OutcomeHumansLung NeoplasmsMaleMiddle AgedNeoplasm StagingRadiography, ThoracicRetreatmentTomography, X-Ray ComputedTreatment OutcomeAngiogenesis InhibitorsAntineoplastic AgentsBevacizumabbevacizumabchemotherapynon-small cell lung cancer

Identifiers

PMID26418066
PMCPMC4847824

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.