ArticlePloS one2015
B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidate.Clinical microbiology reviews · 2025Review
- Human Bocavirus in Childhood: A True Respiratory Pathogen or a "Passenger" Virus? A Comprehensive Review.Microorganisms · 2023Review
- Comparison of MT-PCR with Quantitative PCR for Human Bocavirus in Respiratory Samples with Multiple Respiratory Viruses Detection.Diagnostics (Basel, Switzerland) · 2023Article
- Article
- Prevalence, Cell Tropism, and Clinical Impact of Human Parvovirus Persistence in Adenomatous, Cancerous, Inflamed, and Healthy Intestinal Mucosa.Frontiers in microbiology · 2022Article
- pH-Induced Conformational Changes of Human Bocavirus Capsids.Journal of virology · 2021Article
- Article
- Human bocavirus 1 respiratory tract reactivations or reinfections in two adults, contributing to neurological deficits and death.Access microbiology · 2021Article
- Acute human bocavirus 1 infection in child with life-threatening bilateral bronchiolitis and right-sided pneumonia: a case report.Journal of medical case reports · 2019Article
- Human Bocavirus Infection Markers in Peripheral Blood and Stool Samples of Children with Acute Gastroenteritis.Viruses · 2018Article
- Epidemiology of HBoV1 infection and relationship with meteorological conditions in hospitalized pediatric patients with acute respiratory illness: a 7-year study in a subtropical region.BMC infectious diseases · 2018Article
- Global Distribution of Human Protoparvoviruses.Emerging infectious diseases · 2018Article
- Serologically diagnosed acute human bocavirus 1 infection in childhood community-acquired pneumonia.Pediatric pulmonology · 2018Article
- Human Parvoviruses.Clinical microbiology reviews · 2017Review
- Epidemiology of two human protoparvoviruses, bufavirus and tusavirus.Scientific reports · 2016Article
- Correction: Vol. 18, No. 2.Emerging infectious diseases · 2016Article
- Mapping Antigenic Epitopes on the Human Bocavirus Capsid.Journal of virology · 2016Article
- Prevalence and Phylogenetic Analysis of Human Bocaviruses 1-4 in Pediatric Patients with Various Infectious Diseases.PloS one · 2016Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human bocaviruses (HBoVs) 1-4 are recently discovered, antigenically similar parvoviruses. We examined the hypothesis that the antigenic similarity of these viruses could give rise to clinically and diagnostically important immunological interactions. IgG and IgM EIAs as well as qPCR were used to study ~2000 sera collected from infancy to early adolescence at 3-6-month intervals from 109 children whose symptoms were recorded. We found that HBoV1-4-specific seroprevalences at age 6 years were 80%, 48%, 10%, and 0%, respectively. HBoV1 infections resulted in significantly weaker IgG responses among children who had pre-existing HBoV2 IgG, and vice versa. Furthermore, we documented a complete absence of virus type-specific immune responses in six viremic children who had pre-existing IgG for another bocavirus, indicating that not all HBoV infections can be diagnosed serologically. Our results strongly indicate that interactions between consecutive HBoV infections affect HBoV immunity via a phenomenon called "original antigenic sin", cross-protection, or both; however, without evident clinical consequences but with important ramifications for the serodiagnosis of HBoV infections. Serological data is likely to underestimate human exposure to these viruses.
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