ArticleeLife2015
Corticostriatal dynamics encode the refinement of specific behavioral variability during skill learning.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 89 citations in OpenAlex.
- Noise-induced hearing loss delays auditory learning and reduces the influence of acoustic evidence on choice.bioRxiv : the preprint server for biology · 2026Article
- Behavior- and Cell Type-Specific Cortico-Striatal Decoupling in a Parkinson's Disease-Like Mouse Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Sharp Waves, Bursts, and Coherence: Activity in a Songbird Vocal Circuit Is Influenced by Behavioral State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Refinement of efficient encodings of movement in the dorsolateral striatum throughout learning.Cell reports · 2025Article
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- Motor learning drives region-specific transcriptomic remodeling in the motor cortex and dorsal striatum.bioRxiv : the preprint server for biology · 2025Article
- Brain complexity represents uncertainty in sequence learning and corroborates habituation deficit in Parkinson disease patients.Scientific reports · 2025Article
- Information flow between motor cortex and striatum reverses during skill learning.Current biology : CB · 2024Article
- Exploration biases forelimb reaching strategies.Cell reports · 2024Article
- Early excitatory-inhibitory cortical modifications following skill learning are associated with motor memory consolidation and plasticity overnight.Nature communications · 2024Article
- Layer 5 Intratelencephalic Neurons in the Motor Cortex Stably Encode Skilled Movement.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Altered motor learning and coordination in mouse models of autism spectrum disorder.Frontiers in cellular neuroscience · 2023Review
- Synaptic Plasticity Is Predicted by Spatiotemporal Firing Rate Patterns and Robust to In Vivo-like Variability.Biomolecules · 2022Article
- Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons.Neuron · 2022Article
- Networking brainstem and basal ganglia circuits for movement.Nature reviews. Neuroscience · 2022Review
- Striatal direct pathway neurons play leading roles in accelerating rotarod motor skill learning.iScience · 2022Article
- Impaired Refinement of Kinematic Variability in Huntington Disease Mice on an Automated Home Cage Forelimb Motor Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Modulation of neural activity in frontopolar cortex drives reward-based motor learning.Scientific reports · 2021Article
- Coupling between motor cortex and striatum increases during sleep over long-term skill learning.eLife · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Learning to perform a complex motor task requires the optimization of specific behavioral features to cope with task constraints. We show that when mice learn a novel motor paradigm they differentially refine specific behavioral features. Animals trained to perform progressively faster sequences of lever presses to obtain reinforcement reduced variability in sequence frequency, but increased variability in an orthogonal feature (sequence duration). Trial-to-trial variability of the activity of motor cortex and striatal projection neurons was higher early in training and subsequently decreased with learning, without changes in average firing rate. As training progressed, variability in corticostriatal activity became progressively more correlated with behavioral variability, but specifically with variability in frequency. Corticostriatal plasticity was required for the reduction in frequency variability, but not for variability in sequence duration. These data suggest that during motor learning corticostriatal dynamics encode the refinement of specific behavioral features that change the probability of obtaining outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.